CAS No. : 58-22-0

Product Details
Cat No:R065023
Synonyms:17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone
Molecular Formula:C19H28O2
Molecular Weight:288.4
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Appearance: Powder
Purity: 98.0%
Cat No:R065023
Cas No:58-22-0
Testosterone is the primary male sex hormone and an anabolic steroid. In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. In addition, testosterone is involved in health and well-being, and the prevention of osteoporosis. Insufficient levels of testosterone in men may lead to abnormalities including frailty and bone loss.
Testosterone is also used as a medication to treat male hypogonadism and certain types of breast cancer. Since testosterone levels gradually decrease as men age, synthetic testosterone is sometimes prescribed to older men to counteract this deficiency.
Testosterone is a steroid from the androstane class containing a keto and hydroxyl groups at the three and seventeen positions respectively. It is biosynthesized in several steps from cholesterol and is converted in the liver to inactive metabolites. It exerts its action through binding to and activation of the androgen receptor.
In humans and most other vertebrates, testosterone is secreted primarily by the testicles of males and, to a lesser extent, the ovaries of females. Small amounts are also secreted by the adrenal glands. On average, in adult males, levels of testosterone are about 7–8 times as great as in adult females. As the metabolic consumption of testosterone in males is greater, the daily production is about 20 times greater in men. Females are also more sensitive to the hormone.
1: Rashid O, Ram N, Farooq S, Kiran Z. Idiopathic hypogonadotropic hypogonadism reversal after testosterone replacement in a 34-year-old male. BMJ Case Rep. 2017 Jun 5;2017. pii: bcr-2016-218729. doi: 10.1136/bcr-2016-218729. PubMed PMID: 28583920.
2: Reardon KW, Herzhoff K, Tackett JL. Adolescent Personality as Risk and Resiliency in the Testosterone-Externalizing Association. J Res Adolesc. 2016 Sep;26(3):390-402. doi: 10.1111/jora.12198. Epub 2015 Mar 6. PubMed PMID: 28581652.
3: Moon H, Choi I, Kim S, Ko H, Shin J, Lee K, Sung J, Song YM. Cross-sectional association between testosterone, sex hormone-binding globulin and metabolic syndrome: The Healthy Twin Study. Clin Endocrinol (Oxf). 2017 Jun 5. doi: 10.1111/cen.13390. [Epub ahead of print] PubMed PMID: 28581026.
4: Liu CC, Huang SP, Cheng KH, Hsieh TJ, Huang CN, Wang CJ, Yeh HC, Tsai CC, Bao BY, Wu WJ, Lee YC. Lower SHBG level is associated with higher leptin and lower adiponectin levels as well as metabolic syndrome, independent of testosterone. Sci Rep. 2017 Jun 2;7(1):2727. doi: 10.1038/s41598-017-03078-0. PubMed PMID: 28577342.
5: Gordon I, Pratt M, Bergunde K, Zagoory-Sharon O, Feldman R. Testosterone, oxytocin, and the development of human parental care. Horm Behav. 2017 May 30. pii: S0018-506X(16)30527-X. doi: 10.1016/j.yhbeh.2017.05.016. [Epub ahead of print] PubMed PMID: 28576647.
6: Choi JC, Park YH, Park SK, Lee JS, Kim J, Choi JI, Yoon KB, Lee S, Lim DE, Choi JY, Kim MH, Park G, Choi SS, Lee JM. Testosterone effects on pain and brain activation patterns. Acta Anaesthesiol Scand. 2017 Jul;61(6):668-675. doi: 10.1111/aas.12908. PubMed PMID: 28573655.
7: Nolan BJ, Grossmann M. Testosterone treatment in older men: glass half empty or half full? Asian J Androl. 2017 May 26. doi: 10.4103/aja.aja_14_17. [Epub ahead of print] PubMed PMID: 28566558.
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