A large number of synthetic cannabinoids (CBs) have been detected in herbal blends sold for recreational use. 1’-Naphthoyl indole represents the simplest form of this group of cannabimimetics. While the addition of an N-alkyl chain of four or more carbons generates compounds which potently activate CB receptors, short chain lengths are inactive at both central CB1 and peripheral CB2. This suggests that 1’-naphthoyl indole should have no appreciable affinity for either receptor. 1’-Naphthoyl-2-methylindole differs structurally from 1’-naphthoyl indole by having a methyl group attached at the two position of the indole ring. The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.
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