(25S)-Δ7-Dafachronic Acid


CAS No. : 949004-12-0

(25S)-Δ7-Dafachronic Acid,949004-12-0
Product Details
Cat No:R064644
Synonyms:UPF-1404
Molecular Formula:C27H42O3
Molecular Weight:414.63
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Cat No:R064644
Cas No:949004-12-0
Product-Name:(25S)-Δ7-Dafachronic Acid
IUPAC Name:(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
InChI:InChI=1S/C27H42O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h9,17-19,22-24H,5-8,10-16H2,1-4H3,(H,29,30)/t17-,18+,19+,22-,23+,24+,26+,27-/m1/s1
InChIKey:SQTAVUCHOVVOFD-OBRBSRNPSA-N
SMILES:CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2=CCC4C3(CCC(=O)C4)C)C
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ At 50 nM, (25S)-Δ Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.
1.Ogawa, A.,Streit, A.,Antebi, A., et al. A conserved endocrine mechanism controls the formation of dauer and infective larvae in nematodes. Current Biology 19, 67-71 (2009).
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