(R)-Sertaconazole


CAS No. : 583057-48-1

(R)-Sertaconazole,583057-48-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R057637
Synonyms:1-[(2R)-2-[(7-Chlorobenzo[b]thien-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-Imidazole; Arasertaconazole;
Molecular Formula:C20H15Cl3N2OS
Molecular Weight:437.763
Target:sterol-14-alpha demethylation inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:R057637
Cas No:583057-48-1
Product-Name:(R)-Sertaconazole
IUPAC Name:1-[(2R)-2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
InChI:InChI=1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2/t19-/m0/s1
InChIKey:JLGKQTAYUIMGRK-IBGZPJMESA-N
SMILES:C1=CC2=C(C(=C1)Cl)SC=C2COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl
Arasertaconazole is a sterol-14-alpha demethylation inhibitor potentially for treatment of vulvovaginal candcanidiasis.

1:Sertaconazole nitrate loaded nanovesicular systems for targeting skin fungal infection: in-vitro, ex-vivo and in-vivo evaluation. Abdellatif MM, Khalil IA, Khalil MAF.Int J Pharm. 2017 May 15. pii: S0378-5173(17)30441-6. doi: 10.1016/j.ijpharm.2017.05.029. [Epub ahead of print] PMID: 28522423
2:Microemulsion loaded hydrogel as a promising vehicle for dermal delivery of the antifungal sertaconazole: design, optimization and ex vivo evaluation. Radwan SAA, ElMeshad AN, Shoukri RA.Drug Dev Ind Pharm. 2017 Apr 27:1-15. doi: 10.1080/03639045.2017.1318899. [Epub ahead of print] PMID: 28420288
3:Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study. Chatterjee D, Ghosh SK, Sen S, Sarkar S, Hazra A, De R.Indian J Pharmacol. 2016 Nov-Dec;48(6):659-664. doi: 10.4103/0253-7613.194850. PMID: 28066103 Free PMC Article
4:Design expert assisted formulation of topical bioadhesive gel of sertaconazole nitrate. Pande V, Patel S, Patil V, Sonawane R.Adv Pharm Bull. 2014;4(2):121-30. doi: 10.5681/apb.2014.019. Epub 2013 Dec 24. PMID: 24511475 Free PMC Article
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