(±)-JWH 018 N-(4-hydroxypentyl) metabolite

CAS No. : 1320363-47-0

(±)-JWH 018 N-(4-hydroxypentyl) metabolite,1320363-47-0
Product Details
Cat No:R049866
Molecular Formula:C24H23NO2
Molecular Weight:357.453
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Cat No:R049866
Cas No:1320363-47-0
Product-Name:(±)-JWH 018 N-(4-hydroxypentyl) metabolite
IUPAC Name:[1-(4-hydroxypentyl)indol-3-yl]-naphthalen-1-ylmethanone
JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06. JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. (±)-JWH 018 N-(4-hydroxypentyl) metabolite is a urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain. Its biological actions are unknown.
1.Aung, M.M.,Griffin, G.,Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60, 133-140 (2000).
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