(±)-JWH 018 N-(4-hydroxypentyl) metabolite


CAS No. : 1320363-47-0

(±)-JWH 018 N-(4-hydroxypentyl) metabolite,1320363-47-0
Product Details
Cat No:R049866
Synonyms:(1-(4-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)-methanone
Molecular Formula:C24H23NO2
Molecular Weight:357.453
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Cat No:R049866
Cas No:1320363-47-0
Product-Name:(±)-JWH 018 N-(4-hydroxypentyl) metabolite
IUPAC Name:[1-(4-hydroxypentyl)indol-3-yl]-naphthalen-1-ylmethanone
InChI:InChI=1S/C24H23NO2/c1-17(26)8-7-15-25-16-22(20-12-4-5-14-23(20)25)24(27)21-13-6-10-18-9-2-3-11-19(18)21/h2-6,9-14,16-17,26H,7-8,15H2,1H3
InChIKey:LLFBQQHYZJTRAS-UHFFFAOYSA-N
SMILES:CC(CCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43)O
JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06. JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. (±)-JWH 018 N-(4-hydroxypentyl) metabolite is a urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain. Its biological actions are unknown.
1.Aung, M.M.,Griffin, G.,Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60, 133-140 (2000).
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