β-Glycyrrhetinic acid


CAS No. : 471-53-4

β-Glycyrrhetinic acid,471-53-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R048750
Synonyms:(3β,20β)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid; 3β-Hydroxy-11-oxo-olean- 12-en-30-oic Acid; Uralenic Acid; 18β-Glycyrrhetic Acid; 18β-Glycyrrhetinic Acid; Arthrodont; Biosone; Enoxolone; GM 1658; Glycyrrhetin; Glycyrrhetinic acid; NSC 35347; PO 12;
Molecular Formula:C30H46O4
Molecular Weight:470.694
Target:11β-Hydroxysteroid Dehydrogenase Inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:R048750
Cas No:471-53-4
Product-Name:β-Glycyrrhetinic acid
IUPAC Name:(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
MDL No:MFCD00003706
InChI:InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
InChIKey:MPDGHEJMBKOTSU-YKLVYJNSSA-N
SMILES:CC1(C2CCC3(C(C2(CCC1O)C)C(=O)C=C4C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C
Enoxolone, also known as Glycyrrhetic acid, is an 11β-hydroxysteroid dehydrogenase inhibitor used to treat inflammation. Enoxolone is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.

1:Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo. Jeon YD, Kang SH, Bang KS, Chang YN, Lee JH, Jin JS.Molecules. 2016 Apr 22;21(4):523. doi: 10.3390/molecules21040523. PMID: 27110761 Free Article
2:Synthesis and biological evaluation of novel hydrogen sulfide releasing glycyrrhetic acid derivatives. Song H, Sun Y, Xu G, Hou B, Ao G.J Enzyme Inhib Med Chem. 2016 Dec;31(6):1457-63. doi: 10.3109/14756366.2016.1144596. Epub 2016 Feb 21. PMID: 26899462
3:Modulation of Cytochrome P450 Activity by 18β-Glycyrrhetic Acid and its Consequence on Buspirone Pharmacokinetics in Rats. Kim SB, Cho HJ, Kim YS, Kim DD, Yoon IS.Phytother Res. 2015 Aug;29(8):1188-94. doi: 10.1002/ptr.5365. Epub 2015 May 23. PMID: 26010440
4:Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin. Yuan R, Zheng F, Zhong S, Tao X, Zhang Y, Gao F, Yao F, Chen J, Chen Y, Shi G.Molecules. 2014 Aug 28;19(9):13305-18. doi: 10.3390/molecules190913305. PMID: 25170951 Free Article
5:A novel approach for fluorescent visualization of glycyrrhetic acid on a cell with a quantum dot. Hou J, Shi Q, Cao M, Pan P, Ge G, Fan X, Bai G, Xin Y.Biochemistry (Mosc). 2014 Jan;79(1):25-30. doi: 10.1134/S0006297914010040. PMID: 24512660 Free Article
6:Stress degradation studies and stability-indicating TLC-densitometric method of glycyrrhetic acid. Musharraf SG, Kanwal N, Arfeen QU.Chem Cent J. 2013 Jan 17;7(1):9. doi: 10.1186/1752-153X-7-9. PMID: 23327365 Free PMC Article
7:Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. Shi Q, Hou Y, Hou J, Pan P, Liu Z, Jiang M, Gao J, Bai G.PLoS One. 2012;7(9):e44921. doi: 10.1371/journal.pone.0044921. Epub 2012 Sep 27. PMID: 23028680 Free PMC Article
8:A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy. Li S, Qiu YQ, Zhang SH, Gao YH.Skin Pharmacol Physiol. 2012;25(5):257-68. doi: 10.1159/000339652. Epub 2012 Jul 24. PMID: 22832704
9:Enhanced transdermal delivery of 18β-glycyrrhetic acid via elastic vesicles: in vitro and in vivo evaluation. Li S, Qiu Y, Zhang S, Gao Y.Drug Dev Ind Pharm. 2012 Jul;38(7):855-65. doi: 10.3109/03639045.2011.630395. Epub 2011 Nov 11. PMID: 22077323
10:A new approach in the first-line treatment of bacterial and mycotic vulvovaginitis with topical lipohydroperoxides and glycyrrhetic acid: a comparative study. Mainini G, Rotondi M, Scaffa C.Clin Exp Obstet Gynecol. 2011;38(3):243-6. PMID: 21995156
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