Eicosapentaenoic acid (EPA; Item No. 90110) is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE (Item No. 50861), relaxes vascular and airway smooth muscle by activating large conductance Ca (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.
1.Barbosa-Sicard, E.,Markovic, M.,Honeck, H., et al. Eicosapentaenoic acid metabolism by cytochrome P450 enzymes of the CYP2C subfamily. Biochemical and Biophysical Research Communications 329, 1275-1281 (2005).