(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime


CAS No. : 1170613-55-4

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime,1170613-55-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R040884
Synonyms:A 967079
Molecular Formula:C12H14FNO
Molecular Weight:207.3
Target:TRP Channel
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Appearance:Solid powder
Purity: > 98%
Cat No:R040884
Cas No:1170613-55-4
Product-Name:(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime
InChI:InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
InChIKey:HKROEBDHHKMNBZ-CHBKHGQFSA-N
SMILES:FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1
A-967079 is a selective TRPA1 channel blocker.

1: Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi MC, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari R, Geppetti P, Cabrini G. Transient Receptor Potential Ankyrin 1 Channels Modulate Inflammatory Response in Respiratory Cells from Patients with Cystic Fibrosis. Am J Respir Cell Mol Biol. 2016 Nov;55(5):645-656. PubMed PMID: 27281024.
2: Wang S, Zhai C, Zhang Y, Yu Y, Zhang Y, Ma L, Li S, Qiao Y. Cardamonin, a Novel Antagonist of hTRPA1 Cation Channel, Reveals Therapeutic Mechanism of Pathological Pain. Molecules. 2016 Aug 29;21(9). pii: E1145. doi: 10.3390/molecules21091145. PubMed PMID: 27589700.
3: Chen Z, Du S, Kong C, Zhang Z, Mokhtar AD. Intrathecal administration of TRPA1 antagonists attenuate cyclophosphamide-induced cystitis in rats with hyper-reflexia micturition. BMC Urol. 2016 Jun 17;16(1):33. doi: 10.1186/s12894-016-0150-x. PubMed PMID: 27315798; PubMed Central PMCID: PMC4912737.
4: Trevisan G, Benemei S, Materazzi S, De Logu F, De Siena G, Fusi C, Fortes Rossato M, Coppi E, Marone IM, Ferreira J, Geppetti P, Nassini R. TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress. Brain. 2016 May;139(Pt 5):1361-77. doi: 10.1093/brain/aww038. PubMed PMID: 26984186.
5: Huang Q, Chen Y, Gong N, Wang YX. Methylglyoxal mediates streptozotocin-induced diabetic neuropathic pain via activation of the peripheral TRPA1 and Nav1.8 channels. Metabolism. 2016 Apr;65(4):463-74. doi: 10.1016/j.metabol.2015.12.002. PubMed PMID: 26975538.
6: Patel R, Brice NL, Lewis RJ, Dickenson AH. Ionic mechanisms of spinal neuronal cold hypersensitivity in ciguatera. Eur J Neurosci. 2015 Dec;42(11):3004-11. doi: 10.1111/ejn.13098. PubMed PMID: 26454262; PubMed Central PMCID: PMC4744673.
7: Sałat K, Filipek B. Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B. 2015 Mar;16(3):167-78. doi: 10.1631/jzus.B1400189. PubMed PMID: 25743118; PubMed Central PMCID: PMC4357366.
8: Zhai C, Liu Q, Zhang Y, Wang S, Zhang Y, Li S, Qiao Y. Identification of natural compound carnosol as a novel TRPA1 receptor agonist. Molecules. 2014 Nov 14;19(11):18733-46. doi: 10.3390/molecules191118733. PubMed PMID: 25405290.
9: Banzawa N, Saito S, Imagawa T, Kashio M, Takahashi K, Tominaga M, Ohta T. Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist. J Biol Chem. 2014 Nov 14;289(46):31927-39. doi: 10.1074/jbc.M114.586891. PubMed PMID: 25271161; PubMed Central PMCID: PMC4231671.
10: Saarnilehto M, Chapman H, Savinko T, Lindstedt K, Lauerma AI, Koivisto A. Contact sensitizer 2,4-dinitrochlorobenzene is a highly potent human TRPA1 agonist. Allergy. 2014 Oct;69(10):1424-7. doi: 10.1111/all.12488. PubMed PMID: 25041656.
11: de Oliveira C, Garami A, Lehto SG, Pakai E, Tekus V, Pohoczky K, Youngblood BD, Wang W, Kort ME, Kym PR, Pinter E, Gavva NR, Romanovsky AA. Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci. 2014 Mar 26;34(13):4445-52. doi: 10.1523/JNEUROSCI.5387-13.2014. PubMed PMID: 24671991; PubMed Central PMCID: PMC3965775.
12: Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A. TRPA1: a transducer and amplifier of pain and inflammation. Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):50-5. doi: 10.1111/bcpt.12138. Review. PubMed PMID: 24102997.
13: Wei H, Saarnilehto M, Falck L, Viisanen H, Lasierra M, Koivisto A, Pertovaara A. Spinal transient receptor potential ankyrin 1 channel induces mechanical hypersensitivity, increases cutaneous blood flow, and mediates the pronociceptive action of dynorphin A. J Physiol Pharmacol. 2013 Jun;64(3):331-40. PubMed PMID: 23959730.
14: Nakatsuka K, Gupta R, Saito S, Banzawa N, Takahashi K, Tominaga M, Ohta T. Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences. J Mol Neurosci. 2013 Nov;51(3):754-62. doi: 10.1007/s12031-013-0060-2. PubMed PMID: 23872983.
15: Schwartz ES, La JH, Scheff NN, Davis BM, Albers KM, Gebhart GF. TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci. 2013 Mar 27;33(13):5603-11. doi: 10.1523/JNEUROSCI.1806-12.2013. PubMed PMID: 23536075; PubMed Central PMCID: PMC3690366.
16: Klement G, Eisele L, Malinowsky D, Nolting A, Svensson M, Terp G, Weigelt D, Dabrowski M. Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore. Biophys J. 2013 Feb 19;104(4):798-806. doi: 10.1016/j.bpj.2013.01.008. PubMed PMID: 23442958; PubMed Central PMCID: PMC3576529.
17: Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology. 2012 Jul;117(1):137-48. doi: 10.1097/ALN.0b013e31825adb0e. PubMed PMID: 22588108.
18: Chen J, Joshi SK, DiDomenico S, Perner RJ, Mikusa JP, Gauvin DM, Segreti JA, Han P, Zhang XF, Niforatos W, Bianchi BR, Baker SJ, Zhong C, Simler GH, McDonald HA, Schmidt RG, McGaraughty SP, Chu KL, Faltynek CR, Kort ME, Reilly RM, Kym PR. Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain. 2011 May;152(5):1165-72. doi: 10.1016/j.pain.2011.01.049. PubMed PMID: 21402443.
19: Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, Huang JL, Wang YX, Pertovaara A. Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain. 2011 Mar;152(3):582-91. doi: 10.1016/j.pain.2010.11.031. PubMed PMID: 21211906.
20: McGaraughty S, Chu KL, Perner RJ, Didomenico S, Kort ME, Kym PR. TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol Pain. 2010 Mar 5;6:14. doi: 10.1186/1744-8069-6-14. PubMed PMID: 20205719; PubMed Central PMCID: PMC2841076.

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