GW-842166X


CAS No. : 666260-75-9

GW-842166X,666260-75-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R039808
Synonyms:2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide; 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic Acid [(tetrahydropyran-4-yl)methyl]amide; GW 842166;
Molecular Formula:C18H17Cl2F3N4O2
Molecular Weight:449.3
Target:Cannabinoid Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:R039808
Cas No:666260-75-9
Product-Name:GW-842166X
InChI:InChI=1S/C18H17Cl2F3N4O2/c19-11-1-2-14(13(20)7-11)26-17-25-9-12(15(27-17)18(21,22)23)16(28)24-8-10-3-5-29-6-4-10/h1-2,7,9-10H,3-6,8H2,(H,24,28)(H,25,26,27)
InChIKey:TWQYWUXBZHPIIV-UHFFFAOYSA-N
SMILES:Clc1ccc(Nc2ncc(C(=O)NCC3CCOCC3)c(n2)C(F)(F)F)c(Cl)c1
GW 842166X is a cannabinoid receptor 2 (CB2) agonist potentially for the treatment of inflammatory pain.

1: Chen JJ, Han S, Cao Y, Chen JZ. The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies. Yao Xue Xue Bao. 2013 Sep;48(9):1436-49. PubMed PMID: 24358778.
2: Petrov RR, Ferrini ME, Jaffar Z, Thompson CM, Roberts K, Diaz P. Design and evaluation of a novel fluorescent CB2 ligand as probe for receptor visualization in immune cells. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5859-62. doi: 10.1016/j.bmcl.2011.07.099. PubMed PMID: 21855337; PubMed Central PMCID: PMC3171627.
3: Ostenfeld T, Price J, Albanese M, Bullman J, Guillard F, Meyer I, Leeson R, Costantin C, Ziviani L, Nocini PF, Milleri S. A randomized, controlled study to investigate the analgesic efficacy of single doses of the cannabinoid receptor-2 agonist GW842166, ibuprofen or placebo in patients with acute pain following third molar tooth extraction. Clin J Pain. 2011 Oct;27(8):668-76. doi: 10.1097/AJP.0b013e318219799a. PubMed PMID: 21540741.
4: Giblin GM, O/'Shaughnessy CT, Naylor A, Mitchell WL, Eatherton AJ, Slingsby BP, Rawlings DA, Goldsmith P, Brown AJ, Haslam CP, Clayton NM, Wilson AW, Chessell IP, Wittington AR, Green R. Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600. PubMed PMID: 17477516.

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