(+)-Cloprostenol methyl ester


CAS No. : 56687-85-5

(+)-Cloprostenol methyl ester,56687-85-5
Product Details
Cat No:R033002
Synonyms:D-Cloprostenol methyl ester;(+)-16-m-Chlorophenoxy tetranor PGF2α methyl ester
Molecular Formula:C23H31ClO6
Molecular Weight:438.9
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Cat No:R033002
Cas No:56687-85-5
Product-Name:(+)-Cloprostenol methyl ester
InChI:InChI=1S/C23H31ClO6/c1-29-23(28)10-5-3-2-4-9-19-20(22(27)14-21(19)26)12-11-17(25)15-30-18-8-6-7-16(24)13-18/h2,4,6-8,11-13,17,19-22,25-27H,3,5,9-10,14-15H2,1H3/b4-2-,12-11+/t17-,19-,20-,21+,22-/m1/s1
InChIKey:DVBATKLFQCCUII-OWEKAKITSA-N
SMILES:ClC1=CC(OC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=CCCCC(OC)=O)=CC=C1
(+)-Cloprostenol is a synthetic analog of prostaglandin F (PGF). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprostenol methyl ester is a more lipid soluble form of cloprostenol, which may be more amenable for certain formulations.
1.Dukes, M.,Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250, 330-331 (1974).
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