(2R)-Octyl-α-hydroxyglutarate-d17


CAS No. : NA

(2R)-Octyl-α-hydroxyglutarate-d17,NA
Product Details
Cat No:R031426
Synonyms:(2R)-2-Hydroxypentanedioic Acid 1-Octyl Ester-d17
Molecular Formula:C13H7D17O5
Molecular Weight:277.4
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Assay:≥99% deuterated forms (d1-d17)
Appearance:A crystalline solid
Cat No:R031426
Cas No:NA
Product-Name:(2R)-Octyl-α-hydroxyglutarate-d17
InChIKey:UJZOKTKSGUOCCM-XDYCJWJQSA-N
α-Hydroxyglutaric acid (2-HG; Item No. 16374) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate. 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. (2R)-Octyl-α-hydroxyglutarate-d17 is intended for use as an internal standard for the quantification of (2R)-octyl-α-hydroxyglutarate (Item No. 16366) by GC- or LC-MS. (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2-HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.
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