(S)-(-)-PH-797804


CAS No. : 1358027-80-1

(S)-(-)-PH-797804,1358027-80-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R024553
Synonyms:(Sa)-(-)-3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide; (3S)​-3-​[3-​bromo-​4-​[(2,​4-​difluorophenyl)​methoxy]​-​6-​methyl-​2-​oxo-​1(2H)​-​pyridinyl]​-​N,​4-​dimethyl-benzamide
Molecular Formula:C22H19BrF2N2O3
Molecular Weight:477.306
Target:p38 MAPK inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:R024553
Cas No:1358027-80-1
Product-Name:(S)-(-)-PH-797804
IUPAC Name:3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide
InChI:InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)
InChIKey:KCAJXIDMCNPGHZ-UHFFFAOYSA-N
SMILES:CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C
PH-797804 is a p38 MAPK inhibitor potentially for the treatment of chronic obstructive pulmonary disease

1:Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial. MacNee W, Allan RJ, Jones I, De Salvo MC, Tan LF.Thorax. 2013 Aug;68(8):738-45. doi: 10.1136/thoraxjnl-2012-202744. Epub 2013 Mar 28. PMID: 23539534
2:Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate. Xing L, Devadas B, Devraj RV, Selness SR, Shieh H, Walker JK, Mao M, Messing D, Samas B, Yang JZ, Anderson GD, Webb EG, Monahan JB.ChemMedChem. 2012 Feb 6;7(2):273-80. doi: 10.1002/cmdc.201100439. Epub 2011 Dec 15. PMID: 22174080
3:Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Xing L, Shieh HS, Selness SR, Devraj RV, Walker JK, Devadas B, Hope HR, Compton RP, Schindler JF, Hirsch JL, Benson AG, Kurumbail RG, Stegeman RA, Williams JM, Broadus RM, Walden Z, Monahan JB.Biochemistry. 2009 Jul 14;48(27):6402-11. doi: 10.1021/bi900655f. PMID: 19496616
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