(±)8(9)-DiHET Lipid Maps® MS Standard


CAS No. :

(±)8(9)-DiHET Lipid Maps® MS Standard,
Product Details
Cat No:R016320
Synonyms:(±)8,9-DiHETrE
Molecular Formula:C20H34O4
Molecular Weight:338.5
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Cat No:R016320
Product-Name:(±)8(9)-DiHET Lipid Maps® MS Standard
InChI:InChI=1S/C20H34O4/c1-2-3-4-5-6-7-8-9-12-15-18(21)19(22)16-13-10-11-14-17-20(23)24/h6-7,9-10,12-13,18-19,21-22H,2-5,8,11,14-17H2,1H3,(H,23,24)/b7-6-,12-9-,13-10-/t18-,19+/m1/s1
InChIKey:DCJBINATHQHPKO-ZZMPYBMWSA-N
SMILES:O[C@H](C/C=CC/C=CCCCCC)[C@H](C/C=CCCCC(O)=O)O
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
1.Oliw, E.H.,Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. The Journal of Biological Chemisty 257, 3771-3781 (1982).
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