(S)-Carisbamate


CAS No. : 194085-75-1

(S)-Carisbamate,194085-75-1
Product Details
Cat No:R013510
Synonyms:(1S)-1-(2-Chlorophenyl)-1,2-ethanediol 2-Carbamate; JNJ 10234094; RWJ 333369; YKP 509;
Molecular Formula:C₉H₁₀ClNO₃
Molecular Weight:215.63
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Appearance:Solid powder
Purity: > 98%
Cat No:R013510
Cas No:194085-75-1
Product-Name:(S)-Carisbamate
Carisbamate, also known as JNJ-10234094, RWJ 333369 and YKP-509, is an antiepileptic candidate. Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy. Carisbamate inhibits glutamate transmission in the granule cell of the dentate gyrus. Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms.

1:On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model. Mangubat EZ, Kellogg RG, Harris TJ Jr, Rossi MA.J Neurosurg. 2015 Jun;122(6):1283-92. doi: 10.3171/2015.1.JNS14946. Epub 2015 Feb 27. PMID: 25723302
2:Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain. Shim S, El Mansari M, Blier P.J Pharmacol Exp Ther. 2013 Nov;347(2):487-96. doi: 10.1124/jpet.113.203315. Epub 2013 Aug 28. PMID: 23986541 Free Article
3:Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials. Smith T, DiBernardo A, Shi Y, Todd MJ, Brashear HR, Ford LM.Pain Pract. 2014 Apr;14(4):332-42. doi: 10.1111/papr.12080. Epub 2013 May 22. PMID: 23692321
4:A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus. Faure JB, Akimana G, Carneiro JE, Cosquer B, Ferrandon A, Geiger K, Koning E, Penazzi L, Cassel JC, Nehlig A.Epilepsia. 2013 Jul;54(7):1203-13. doi: 10.1111/epi.12219. Epub 2013 May 11. PMID: 23663139 Free Article
5:RP-HPLC separation and ESI-MS, 1H, and 13C NMR characterization of forced degradants including process related impurities of carisbamate: method development and validation. Rao RN, Ramakrishna K, Sravan B, Santhakumar K.J Pharm Biomed Anal. 2013 Apr 15;77:49-54. doi: 10.1016/j.jpba.2013.01.001. Epub 2013 Jan 8. PMID: 23376724
6:Effect of carisbamate on the pharmacokinetics and pharmacodynamics of warfarin in healthy participants. Gonzalez M, Zannikos P, DiBernardo A, Brashear HR, Ariyawansa J.J Clin Pharmacol. 2012 Sep;52(9):1420-9. doi: 10.1177/0091270011415412. Epub 2011 Oct 19. PMID: 22011511
7:Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studies. Meador KJ, Brashear HR, Wiegand F, Zannikos P, Novak G.Epilepsy Behav. 2011 Oct;22(2):324-30. doi: 10.1016/j.yebeh.2011.07.006. Epub 2011 Aug 17. PMID: 21849260
8:Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus. Lee CY, Lee ML, Shih CC, Liou HH.Neuropharmacology. 2011 Dec;61(8):1239-47. doi: 10.1016/j.neuropharm.2011.07.022. Epub 2011 Jul 30. PMID: 21824485
9:Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms. Ono T, Moshé SL, Galanopoulou AS.Epilepsia. 2011 Sep;52(9):1678-84. doi: 10.1111/j.1528-1167.2011.03173.x. Epub 2011 Jul 19. PMID: 21770922 Free PMC Article
10:Effect of mild and moderate hepatic impairment on the pharmacokinetics and safety of carisbamate. Moore K, Zannikos P, Solanki B, Greenspan A, Verhaeghe T, Brashear HR.J Clin Pharmacol. 2012 May;52(5):738-46. doi: 10.1177/0091270011403313. Epub 2011 May 12. PMID: 21566203
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