(S)-Indan-1-yl 3,4-dichlorobenzylcarbamate


CAS No. : 582314-48-5

(S)-Indan-1-yl 3,4-dichlorobenzylcarbamate,582314-48-5
Product Details
Cat No:R008735
Synonyms:(S)-Indan-1-yl 3,4-dichlorobenzylcarbamate
Molecular Formula:C17H15Cl2NO2
Molecular Weight:336.212
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Cat No:R008735
Cas No:582314-48-5
Product-Name:(S)-Indan-1-yl 3,4-dichlorobenzylcarbamate
IUPAC Name:[(1S)-2,3-dihydro-1H-inden-1-yl] N-[(3,4-dichlorophenyl)methyl]carbamate
InChI:InChI=1S/C17H15Cl2NO2/c18-14-7-5-11(9-15(14)19)10-20-17(21)22-16-8-6-12-3-1-2-4-13(12)16/h1-5,7,9,16H,6,8,10H2,(H,20,21)/t16-/m0/s1
InChIKey:CKERQCMQSBFFKX-INIZCTEOSA-N
SMILES:C1CC2=CC=CC=C2C1OC(=O)NCC3=CC(=C(C=C3)Cl)Cl
Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 µM. These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.
1.Cecconi, F.,Alvarez-Bolado, G.,Meyer, B.I., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737 (1998).
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