Assay:≥99% deuterated forms (d1-d3)
|Product-Name:||Rapamycin-d3 (contains d0) Technical Grade|
Rapamycin-d3 (Item No. 22093) contains three deuterium atoms at the methyl position. It is intended for use as an internal standard for the quantification of rapamycin (Item No. 13346) by GC- or LC-MS. Rapamycin interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.