(R,S)-Equol


CAS No. : 94105-90-5

(R,S)-Equol,94105-90-5
Product Details
Cat No:R004033
Synonyms:3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol; 4’,7-Isoflavandiol; (+/-)-Equol; 7,4’-Homoisoflavane; NV 07α;
Molecular Formula:C15H14O3
Molecular Weight:242.3
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Appearance:Solid powder
Purity: > 98%
Cat No:R004033
Cas No:94105-90-5
Product-Name:(R,S)-Equol
InChI:InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2
InChIKey:ADFCQWZHKCXPAJ-UHFFFAOYSA-N
SMILES:OC1=CC=C(CC(C2=CC=C(O)C=C2)CO3)C3=C1
Equol is a drug is potentially for the treatment of acute thyroid disease and inhibits proliferation of human gastric carcinoma cells.

1:Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study. Davinelli S, Scapagnini G, Marzatico F, Nobile V, Ferrara N, Corbi G.Maturitas. 2017 Feb;96:77-83. doi: 10.1016/j.maturitas.2016.11.016. Epub 2016 Nov 27. PMID: 28041599
2:Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial. Hazim S, Curtis PJ, Schär MY, Ostertag LM, Kay CD, Minihane AM, Cassidy A.Am J Clin Nutr. 2016 Mar;103(3):694-702. doi: 10.3945/ajcn.115.125690. Epub 2016 Feb 3. PMID: 26843154 Free PMC Article
3:P212A Mutant of Dihydrodaidzein Reductase Enhances (S)-Equol Production and Enantioselectivity in a Recombinant Escherichia coli Whole-Cell Reaction System. Lee PG, Kim J, Kim EJ, Jung E, Pandey BP, Kim BG.Appl Environ Microbiol. 2016 Jan 22;82(7):1992-2002. doi: 10.1128/AEM.03584-15. PMID: 26801575 Free PMC Article
4:S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Lu Z, Zhou R, Kong Y, Wang J, Xia W, Guo J, Liu J, Sun H, Liu K, Yang J, Mi M, Xu H.Curr Cancer Drug Targets. 2016;16(5):455-65. PMID: 26638886
5:HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol. Bertrand SJ, Hu C, Aksenova MV, Mactutus CF, Booze RM.Front Microbiol. 2015 Sep 8;6:894. doi: 10.3389/fmicb.2015.00894. eCollection 2015. PMID: 26441850 Free PMC Article
6:The influence of equol on the hypothalamic-pituitary-thyroid axis and hepatic lipid metabolic parameters in adult male rats. Loutchanwoot P, Srivilai P, Jarry H.Life Sci. 2015 May 1;128:1-7. doi: 10.1016/j.lfs.2015.02.002. Epub 2015 Mar 2. PMID: 25744395
7:S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, Yamaji R.J Nutr Sci Vitaminol (Tokyo). 2014;60(4):291-6. PMID: 25297619 Free Article
8:A survey of equol contents in Chinese stinky tofu with emphasis on the effects of cooking methods. Rui X, Xu X, Wu H, Li W, Chen X, Jiang M, Dong M.Int J Food Sci Nutr. 2014 Sep;65(6):667-72. doi: 10.3109/09637486.2014.908171. Epub 2014 Apr 10. PMID: 24720564
9:Equol induces apoptosis in human hepatocellular carcinoma SMMC-7721 cells through the intrinsic pathway and the endoplasmic reticulum stress pathway. Liang XL, Li M, Li J, Wang XL.Anticancer Drugs. 2014 Jul;25(6):633-40. doi: 10.1097/CAD.0000000000000085. PMID: 24487643
10:Protective effects of equol and their polyphenolic isomers against dermal aging: microarray/protein evidence with clinical implications and unique delivery into human skin. Lephart ED.Pharm Biol. 2013 Nov;51(11):1393-400. doi: 10.3109/13880209.2013.793720. Epub 2013 Jul 18. PMID: 23862588
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