Stiripentol


CAS No. : 49763-96-4

Stiripentol,49763-96-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R003209
Synonyms:1-(1,3-Benzodioxol-5yl)-4,4-dimethyl-1-penten-3-ol; 4,4-Dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol; BCX 2600;
Molecular Formula:C14H18O3
Molecular Weight:234.3
Target:Dehydrogenase
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

Appearance:A crystalline solid
Purity:98%
Cat No:R003209
Cas No:49763-96-4
Product-Name:Stiripentol
IUPAC Name:(E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
InChI:InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
InChIKey:IBLNKMRFIPWSOY-FNORWQNLSA-N
SMILES:IBLNKMRFIPWSOY-FNORWQNLSA-N
Stiripentol(cas 49763-96-4) is an LDH inhibitor. It is a new-generation antiepileptic drug, and its chemical structure is unrelated to other antiepileptic drugs. Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), which is a component of the astrocyte-neuron lactate shuttle
1: Klein P, Tolbert D, Gidal BE. Drug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures. Epilepsy Behav. 2019 Sep 10:106459. doi: 10.1016/j.yebeh.2019.106459. [Epub ahead of print] PubMed PMID: 31519475.
2: Wyatt CM, Drüeke TB. Stiripentol for the treatment of primary hyperoxaluria and calcium oxalate nephropathy. Kidney Int. 2019 Aug 23. pii: S0085-2538(19)30687-8. doi: 10.1016/j.kint.2019.06.011. [Epub ahead of print] PubMed PMID: 31451300.
3: Assimos DG. Re: Stiripentol Protects against Calcium Oxalate Nephrolithiasis and Ethylene Glycol Poisoning. J Urol. 2019 Jul 31:10109701JU0000579360863224f. doi: 10.1097/01.JU.0000579360.86322.4f. [Epub ahead of print] PubMed PMID: 31364941.
4: Yamamoto Y, Takahashi Y, Ikeda H, Imai K, Kagawa Y, Inoue Y. Impact of CYP2C19 phenotypes on clinical efficacy of stiripentol in Japanese patients with Dravet syndrome. Ther Drug Monit. 2019 Jul 15. doi: 10.1097/FTD.0000000000000676. [Epub ahead of print] PubMed PMID: 31318844.
5: Buck ML, Goodkin HP. Stiripentol: A Novel Antiseizure Medication for the Management of Dravet Syndrome. Ann Pharmacother. 2019 Nov;53(11):1136-1144. doi: 10.1177/1060028019856008. Epub 2019 Jun 6. PubMed PMID: 31167540.

Chem Calculators

Recommend Products
  • CAS No. :111984-12-4
    Product Name:

    11-fluorodihydrotestosterone

    Cat No: M020790 View details
  • CAS No. :111850-24-9
    Product Name:

    Phenol, 2,6-bis(1-methylpropyl)-4-(4-nitrophenyl)azo-

    Cat No: M020792 View details
  • CAS No. :125224-62-6
    Product Name:

    (1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptane dihydrobromide

    Cat No: M020794 View details
  • CAS No. :123342-19-8
    Product Name:

    2(1H)-Quinoxalinone, 6-hydroxy-

    Cat No: M020796 View details
  • CAS No. :119687-33-1
    Product Name:

    Iganidipine

    Cat No: M020797 View details
  • CAS No. :114568-26-2
    Product Name:

    4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate

    Cat No: M020798 View details
  • CAS No. :111672-81-2
    Product Name:

    N-[1-(2,5-Dichlorophenyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]-2,2-dimethylpropionamide

    Cat No: M020799 View details
  • CAS No. :115178-97-7
    Product Name:

    20-TRIFLUORO LEUKOTRIENE B4

    Cat No: M020800 View details
  • CAS No. :119171-78-7
    Product Name:

    drummondin C

    Cat No: M020801 View details
  • CAS No. :125288-26-8
    Product Name:

    2-Pentanone, 1,1,1-trifluoro-4-imino-

    Cat No: M020802 View details
  • CAS No. :119354-10-8
    Product Name:

    ORBIFLOXACIN

    Cat No: M020803 View details
  • CAS No. :115474-04-9
    Product Name:

    ENTEROTOXIN STP (E COLI)

    Cat No: M020804 View details