CAS No. : 49763-96-4

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:R003209
Synonyms:1-(1,3-Benzodioxol-5yl)-4,4-dimethyl-1-penten-3-ol; 4,4-Dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol; BCX 2600;
Molecular Formula:C14H18O3
Molecular Weight:234.3
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Appearance:A crystalline solid
Cat No:R003209
Cas No:49763-96-4
IUPAC Name:(E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
Stiripentol(cas 49763-96-4) is an LDH inhibitor. It is a new-generation antiepileptic drug, and its chemical structure is unrelated to other antiepileptic drugs. Seizures and epileptiform activity are reduced by inhibition of the metabolic pathway via lactate dehydrogenase (LDH), which is a component of the astrocyte-neuron lactate shuttle
1: Klein P, Tolbert D, Gidal BE. Drug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures. Epilepsy Behav. 2019 Sep 10:106459. doi: 10.1016/j.yebeh.2019.106459. [Epub ahead of print] PubMed PMID: 31519475.
2: Wyatt CM, Drüeke TB. Stiripentol for the treatment of primary hyperoxaluria and calcium oxalate nephropathy. Kidney Int. 2019 Aug 23. pii: S0085-2538(19)30687-8. doi: 10.1016/j.kint.2019.06.011. [Epub ahead of print] PubMed PMID: 31451300.
3: Assimos DG. Re: Stiripentol Protects against Calcium Oxalate Nephrolithiasis and Ethylene Glycol Poisoning. J Urol. 2019 Jul 31:10109701JU0000579360863224f. doi: 10.1097/01.JU.0000579360.86322.4f. [Epub ahead of print] PubMed PMID: 31364941.
4: Yamamoto Y, Takahashi Y, Ikeda H, Imai K, Kagawa Y, Inoue Y. Impact of CYP2C19 phenotypes on clinical efficacy of stiripentol in Japanese patients with Dravet syndrome. Ther Drug Monit. 2019 Jul 15. doi: 10.1097/FTD.0000000000000676. [Epub ahead of print] PubMed PMID: 31318844.
5: Buck ML, Goodkin HP. Stiripentol: A Novel Antiseizure Medication for the Management of Dravet Syndrome. Ann Pharmacother. 2019 Nov;53(11):1136-1144. doi: 10.1177/1060028019856008. Epub 2019 Jun 6. PubMed PMID: 31167540.

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