Appearance: Powder
Purity: 97.0%
| Cat No: | R003103 |
| Cas No: | 354553-35-8 |
| Product-Name: | Caraphenol A |
| IUPAC Name: | (10R,11R,18S,19S)-3,11,19-tris(4-hydroxyphenyl)-4,12,20-trioxaheptacyclo[16.6.1.12,5.110,13.021,25.09,27.017,26]heptacosa-1(25),2,5,7,9(27),13,15,17(26),21,23-decaene-7,15,23-triol |
| InChI: | InChI=1S/C42H28O9/c43-22-7-1-19(2-8-22)40-37-28-13-25(46)17-32-35(28)39(42(50-32)21-5-11-24(45)12-6-21)30-15-27(48)18-33-36(30)38(29-14-26(47)16-31(49-40)34(29)37)41(51-33)20-3-9-23(44)10-4-20/h1-18,37-38,40-41,43-48H/t37-,38+,40+,41-/m1/s1 |
| InChIKey: | ULEJGXIKBFHUOY-PIQPXYRBSA-N |
| SMILES: | C1=CC(=CC=C1C2C3C4=CC(=CC5=C4C(C(O5)C6=CC=C(C=C6)O)C7=CC(=CC8=C7C(=C(O8)C9=CC=C(C=C9)O)C1=CC(=CC(=C31)O2)O)O)O)O |
Caraphenol A (CAS 354553-35-8), a small molecule closely related to a natural compound called resveratrol, is isolated from caragana sinica. A new study shows that it increased the efficacy of hematopoietic stem cell based gene therapy.
1.Luo, Hong-Feng, Li-Ping Zhang, and Chang-Qi Hu. "Five novel oligostilbenes from the roots of Caragana sinica." Tetrahedron 57.23 (2001): 4849-4854.
2.Ozog, Stosh, et al. "Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes." blood 134.16 (2019): 1298-1311.
3.Wu, Hong, et al. "The cytotoxicity effect of resveratrol: Cell cycle arrest and induced apoptosis of breast Cancer 4T1 cells." Toxins 11.12 (2019): 731.
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