(R,S)-Nornicotine


CAS No. : 5746-86-1

(R,S)-Nornicotine,5746-86-1
Product Details
Cat No:R000337
Synonyms:3-(2-Pyrrolidinyl)pyridine; (±)-1’-Demethylnicotine; (±)-3-(2-Pyrrolidinyl)pyridine; (±)-1’-Demethylnicotine; (±)-Nornicotine; 2-(3-Pyridinyl)pyrrolidine; 3-(Pyrrolidin-2-yl)pyridine;
Molecular Formula:C9H12N2
Molecular Weight:148.209
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Assay:≥95%
Appearance:A crystalline solid
Cat No:R000337
Cas No:5746-86-1
Product-Name:(R,S)-Nornicotine
IUPAC Name:3-pyrrolidin-2-ylpyridine
InChI:InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2
InChIKey:MYKUKUCHPMASKF-UHFFFAOYSA-N
SMILES:C1CC(NC1)C2=CN=CC=C2
(±)-Nornicotine is a metabolite of nicotine (Item No. 16535) that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 µM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.
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