COBRATOXIN (Alpha-)


CAS No. : 69344-74-7

COBRATOXIN (Alpha-),69344-74-7
Product Details
Cat No:P000009
Molecular Formula:C332 H520 N98 O101 S10
Molecular Weight:7,821
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Appearance:White solid
Optical Activity:No optical Activity
Purity:≥ 99% (capillary electrophoresis)
Cat No:P000009
Cas No:69344-74-7
Product-Name:COBRATOXIN (Alpha-)

It is a long chain postsynaptic neurotoxin, antagonist of nicotinic receptor with a high affinity.


A 71-amino acid polypeptide with 5 disulfide Bonds, purified from Naja kaouthia snake venom.

It is a nicotinic cholinoreceptor antagonist: Kd = 55 pM, homologue of postsynaptically acting toxins.


- Ishikawa Y. et al., Toxicon (1977). 15:477-488

- Charpentier I. et al., J. of Molecular Recognition (1990). 3:74-81

- Faure G. et al., Biochemistry (1983). 22:2068-2076

- Karlsson E. et al.,/Isolation of the principal neurotoxins of Naja naja subspecies from the asian mainland./ Toxicon (1972). 10:217-225

- Walkinshaw M.D. et al., Proc. Natl. Acad. Sci. USA (1980). 77:2400-2404

- Betzel C. et al., J. Biol. Chem. (1991). 266:21530-21536



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