(±)16-HETE


CAS No. : 128914-46-5

(±)16-HETE,128914-46-5
Product Details
Cat No:M133235
Synonyms:(±)16-HETE
Molecular Formula:C20H32O3
Molecular Weight:320.5
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Assay:≥98%
Appearance:A solution in ethanol
Cat No:M133235
Cas No:128914-46-5
Product-Name:(±)16-HETE
InChIKey:JEKNPVYFNMZRJG-UFINWASNSA-N
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
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