(1R,6S)-3-HYDROXY-4-METHYL-7-OXABICYCLO[4.1.0]HEPT-3-ENE-2,5-DIONE


CAS No. : 121-40-4

(1R,6S)-3-HYDROXY-4-METHYL-7-OXABICYCLO[4.1.0]HEPT-3-ENE-2,5-DIONE,121-40-4
Product Details
Cat No:M067661
Synonyms:TA;(-)-Terreic Acid
Molecular Formula:C7H6O4
Molecular Weight:154.121
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Assay:≥95%
Appearance:A solid
Cat No:M067661
Cas No:121-40-4
Product-Name:(1R,6S)-3-HYDROXY-4-METHYL-7-OXABICYCLO[4.1.0]HEPT-3-ENE-2,5-DIONE
IUPAC Name:(1S,6R)-4-hydroxy-3-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
InChI:InChI=1S/C7H6O4/c1-2-3(8)5(10)7-6(11-7)4(2)9/h6-8H,1H3/t6-,7+/m1/s1
InChIKey:ATFNSNUJZOYXFC-RQJHMYQMSA-N
SMILES:CC1=C(C(=O)C2C(C1=O)O2)O
Terreic acid (TA) is a cell-permeable quinone epoxide that selectively inhibits Bruton’s tyrosine kinase (BTK) catalytic activity (IC50s = 10 and 3 µM for basal and activation levels, respectively). TA binds to the BTK pleckstrin homology domain (BTK-PH) and blocks the interaction between BTK-PH and PKC (IC50 = 100 µM in human mast cell lysates) without affecting the activity of PKC. TA has minimal effect on Lyn, Syk, PKA, casein kinase I, ERK1, ERK2, and p38 kinase activities.
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