(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid


CAS No. : 191919-02-5

(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid,191919-02-5
Product Details
Cat No:M045447
Synonyms:8-iso-13,14-dihydro-15-keto PGF2α
Molecular Formula:C20H34O5
Molecular Weight:354.5
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Assay:≥98%
Appearance:A solution in methyl acetate
Cat No:M045447
Cas No:191919-02-5
Product-Name:(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid
InChIKey:VKTIONYPMSCHQI-JPRPWBOBSA-N
8-iso-13,14-dihydro-15-keto Prostaglandin F (8-iso-13,14-dihydro-15-keto PGF) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF), in rabbits, monkeys and humans. 8-iso PGF is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits. Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.
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