(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid


CAS No. : 191919-01-4

(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid,191919-01-4
Product Details
Cat No:M038997
Synonyms:8-iso-15-keto PGF2α;8-epi-15-keto PGF2α
Molecular Formula:C20H32O5
Molecular Weight:352.5
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Assay:≥95%
Appearance:A solution in methyl acetate
Cat No:M038997
Cas No:191919-01-4
Product-Name:(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid
InChIKey:LOLJEILMPWPILA-RLXHZABYSA-N
8-iso-15-keto Prostaglandin F (8-iso-15-keto PGF) is a metabolite of the isoprostane 8-iso PGF in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF. 8-iso -15-keto PGF is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.
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