(+)-XESTOSPONGIN B


CAS No. : 123000-02-2

(+)-XESTOSPONGIN B,123000-02-2
Product Details
Cat No:M025597
Synonyms:[1R-(1R*,4aR*,11S*,12aR*,13R*,16aR*,23S*,24aR*)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b’]dipyridine
Molecular Formula:C29H52N2O3
Molecular Weight:476.746
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Assay:≥90%
Appearance:A clear film
Cat No:M025597
Cas No:123000-02-2
Product-Name:(+)-XESTOSPONGIN B
InChI:InChI=1S/C29H52N2O3/c1-23-22-31-19-10-13-24-12-6-2-3-7-14-25-16-21-30-20-11-18-29(32,28(30)33-25)17-9-5-4-8-15-26(23)34-27(24)31/h23-28,32H,2-22H2,1H3/t23-,24-,25+,26+,27-,28-,29?/m1/s1
InChIKey:VJEURJNEIZLTJG-BZFKMGMNSA-N
SMILES:CC1CN2CCCC3C2OC1CCCCCCC4(CCCN5C4OC(CCCCCC3)CC5)O
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties. Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 µM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
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