(3aR)-3,3aβ,4,5,6,6aβ-Hexahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-3-(4α-propylcyclohexan-1α-yl)-1-pro


CAS No. : 101758-79-6

(3aR)-3,3aβ,4,5,6,6aβ-Hexahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-3-(4α-propylcyclohexan-1α-yl)-1-pro,101758-79-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:M001811
Synonyms:(3aR)-3,3aβ,4,5,6,6aβ-Hexahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-3-(4α-propylcyclohexan-1α-yl)-1-propenyl]cyclopenta[b]pyrrole-2-pentanoic acid methyl ester
Molecular Formula:C24H31ClN2O2
Molecular Weight:0
Target:prostacyclin agonist
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Appearance:Solid powder
Purity: > 98%
Cat No:M001811
Cas No:101758-79-6
Product-Name:(3aR)-3,3aβ,4,5,6,6aβ-Hexahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-3-(4α-propylcyclohexan-1α-yl)-1-pro
OP-2507 is a prostacyclin agonist potentially for the treatment of hepatic insufficiency and hypertension.

1: Usui M, Kato H, Kuriyama N, Azumi Y, Kishiwada M, Mizuno S, Sakurai H, Tabata M, Hayashi T, Suzuki K, Isaji S. Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy. Surg Today. 2011 Feb;41(2):230-6. doi: 10.1007/s00595-009-4263-7. PubMed PMID: 21264759.
2: Kurata M, Okajima K, Kawamoto T, Uchiba M, Ohkohchi N. Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. World J Gastroenterol. 2006 Jan 7;12(1):60-5. PubMed PMID: 16440418; PubMed Central PMCID: PMC4077492.
3: Chen MF, Chen JC, Chiu DF, Ng CJ, Shyr MH, Chen HM. Prostacyclin analogue (OP-2507) induces delayed ex vivo neutrophil apoptosis and attenuates reperfusion-induced hepatic microcirculatory derangement in rats. Shock. 2001 Dec;16(6):473-8. PubMed PMID: 11770047.
4: Hirano T, Nakafusa Y, Kawano R, Motoyama K, Arima T, Sugitani A, Tanaka M. The combined use of prostaglandin I2 analogue (OP-2507) and thromboxane A2 synthetase inhibitor (OKY-046) strongly inhibits atherosclerosis of aortic allografts in rats. Surgery. 2001 May;129(5):595-605. PubMed PMID: 11331452.
5: Miura A, Hao Y, Koike Y, Wang LM, Honda Y, Mineshita S. The effect of the prostaglandin I2 analogue OP-2507 on adrenaline-induced pulmonary edema in rabbits and analysis of hemodynamic changes. Jpn J Pharmacol. 2000 Jun;83(2):125-34. PubMed PMID: 10928325.
6: Kuroda H, Kawarada Y, Das BC, Iwata M, Isaji S. Ultrastructural study of the remnant liver after extensive hepatectomy in dogs; especially morphological alterations of sinusoidal endothelial cells. Hepatogastroenterology. 2000 Mar-Apr;47(32):450-4. PubMed PMID: 10791211.
7: Chen HM, Chen MF, Shyr MH. Prostacyclin analogue (OP-2507) attenuates hepatic microcirculatory derangement, energy depletion, and lipid peroxidation in a rat model of reperfusion injury. J Surg Res. 1998 Dec;80(2):333-8. PubMed PMID: 9878334.
8: Iida T, Yokoi H, Kawarada Y. The effects of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analogue on experimental acute necrotizing pancreatitis in rats. Pancreas. 1998 Aug;17(2):140-7. PubMed PMID: 9700944.
9: Ochiai H, Nakamura S, Suzuki S, Baba S. Pancreatic damage resulting from temporary portal triad interruption during partial hepatectomy: protective effect of a prostaglandin I2 analogue. J Surg Res. 1997 Dec;73(2):129-36. PubMed PMID: 9441806.
10: Wang M, Sakon M, Miyoshi H, Umeshita K, Kishimoto S, Taniguchi K, Gotoh M, Imajoh-Ohmi S, Monden M. Prostacyclin analog-suppressed ischemia-reperfusion injury of the rat liver: evaluation by calpain mu activation. J Surg Res. 1997 Dec;73(2):101-6. PubMed PMID: 9441801.
11: Hirano T, Nakafusa Y, Nishinaka H, Takeda K, Kawano R, Nakano M, Arima T, Motoyama K, Nakamura K, Torada N, Ikematsu H, Kamei T, Tanaka M. Effect of prostaglandin I2 analogue and thromboxane A2 synthetase inhibitor on chronic rejection in rats. Transplant Proc. 1997 Feb-Mar;29(1-2):1520. PubMed PMID: 9123408.
12: Kim YI, Yoo YO, Park SH, Lee HI, Joo DH, Park KH, Tanamachi H. Successful transplantation of liver grafts from non-heart-beating donors by synergistic use of prostaglandins (E1 and I2 analogue) and steroids. Transplant Proc. 1997 Feb-Mar;29(1-2):1369-70. PubMed PMID: 9123343.
13: Nawata S, Sugi K, Ueda K, Nawata K, Kaneda Y, Esato K. Prostacyclin analog OP2507 prevents pulmonary arterial and airway constriction during lung preservation and reperfusion. J Heart Lung Transplant. 1996 May;15(5):470-4. PubMed PMID: 8771502.
14: Irita K, Sakai H, Yamakawa M, Nawata H, Yoshitake J, Takahashi S. Effects of OP 2507, a stable analogue of prostaglandin I2, on carbon tetrachloride-induced liver damage in starved rats. Tohoku J Exp Med. 1996 Mar;178(3):279-85. PubMed PMID: 8727710.
15: Goto S, Shimizu Y, Lord R, Vari F, Edwards-Smith C, Chiba S, Kamada N. The beneficial effect of the prostacyclin analogue (OP 2507) on rat liver transplantation subjected to an extended anhepatic phase. Transpl Int. 1996;9(6):607-10. PubMed PMID: 8914245.
16: Mashima S, Shirakami G, Mitsuyoshi A, Nakagami M, Morimoto T, Terasaki M, Nakao K, Yamabe H, Yamaoka Y, Ozawa K. Evaluation of the protective effect of a novel prostacyclin analog on mesenteric circulation following warm ischemia. Eur Surg Res. 1996;28(1):14-25. PubMed PMID: 8682140.
17: Nakano H, Monden M, Umeshita K, Murata M, Miyoshi H, Kanai T, Gotoh M, Mori T. Cytoprotective effect of prostaglandin I2 analogues on superoxide-induced hepatocyte injury. Surgery. 1994 Nov;116(5):883-9. PubMed PMID: 7940193.
18: Kim YI, Kai T, Kitano S, Ishii T, Tatsuma T, Kamada N, Sugimachi K. Hepatoprotection by a PGI2 analogue in complete warm ischemia of the pig liver. Prostanoid release from the reperfused liver. Transplantation. 1994 Oct 27;58(8):875-9. PubMed PMID: 7940729.
19: Umeki S. Prostaglandin E and analogs of prostacyclin influencing superoxide production by the human neutrophil NADPH oxidase system. Int J Biochem. 1994 Aug;26(8):1003-8. PubMed PMID: 8088410.
20: Nakano H, Monden M, Umeshita K, Murata M, Miyoshi H, Kanai T, Gotoh M, Mori T. Protective effects of prostaglandin I2 analogues on superoxide-induced hepatocyte injury. Ann N Y Acad Sci. 1994 Jun 17;723:447-50. PubMed PMID: 8030909.


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