CAS No. : 543-38-4

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I014430
Synonyms:(L)-Canavanine; AI3-52153; AI3 52153; AI352153;Butyric acid, 2-amino-4-(guanidinooxy)-, L-
Molecular Formula:C5H12N4O3
Molecular Weight:176.18
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Appearance:Solid powder
Purity: > 98%
Cat No:I014430
Cas No:543-38-4
(L)-Canavanine has antimutagenic activity.

1: Ntuli SSBN, Gelderblom WCA, Katerere DR. The mutagenic and antimutagenic activity of Sutherlandia frutescens extracts and marker compounds. BMC Complement Altern Med. 2018 Mar 15;18(1):93. doi: 10.1186/s12906-018-2159-z. PubMed PMID: 29544492; PubMed Central PMCID: PMC5856389.
2: Onselen RV, Downing S, Kemp G, Downing T. Investigating β-N-Methylamino-l-alanine Misincorporation in Human Cell Cultures: A Comparative Study with Known Amino Acid Analogues. Toxins (Basel). 2017 Dec 14;9(12). pii: E400. doi: 10.3390/toxins9120400. PubMed PMID: 29240689; PubMed Central PMCID: PMC5744120.
3: Chen YD, Dahanukar A. Molecular and Cellular Organization of Taste Neurons in Adult Drosophila Pharynx. Cell Rep. 2017 Dec 5;21(10):2978-2991. doi: 10.1016/j.celrep.2017.11.041. PubMed PMID: 29212040; PubMed Central PMCID: PMC5736000.
4: Lin MH, Hsu CC, Lin J, Cheng JT, Wu MC. Investigation of morin-induced insulin secretion in cultured pancreatic cells. Clin Exp Pharmacol Physiol. 2017 Dec;44(12):1254-1262. doi: 10.1111/1440-1681.12815. Epub 2017 Sep 18. PubMed PMID: 28699234.
5: Dikmenoğlu Falkmarken NH, Arihan O, Iskit AB. Comparison of endothelin and nitric oxide synthase blockers on hemorheological parameters in endotoxemic rats. Turk J Med Sci. 2017 Jun 12;47(3):1045-1052. doi: 10.3906/sag-1607-19. PubMed PMID: 28618763.
6: Gu C, Yao J, Sun P. Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production. Oncol Lett. 2017 Jun;13(6):4776-4784. doi: 10.3892/ol.2017.6057. Epub 2017 Apr 20. PubMed PMID: 28599479; PubMed Central PMCID: PMC5453014.
7: van Onselen R, Venables L, van de Venter M, Downing TG. β-N-Methylamino-L-Alanine Toxicity in PC12: Excitotoxicity vs. Misincorporation. Neurotox Res. 2018 Jan;33(1):15-23. doi: 10.1007/s12640-017-9743-8. Epub 2017 May 3. PubMed PMID: 28470567.
8: Maneerat K, Yongkiettrakul S, Jiemsup S, Tongtawe P, Gottschalk M, Srimanote P. Expression and Characterization of Serotype 2 Streptococcus suis Arginine Deiminase. J Mol Microbiol Biotechnol. 2017;27(3):133-146. doi: 10.1159/000452952. Epub 2017 Apr 29. PubMed PMID: 28456803.
9: Mathieu C, Macêdo JP, Hürlimann D, Wirdnam C, Haindrich AC, Suter Grotemeyer M, González-Salgado A, Schmidt RS, Inbar E, Mäser P, Bütikofer P, Zilberstein D, Rentsch D. Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PLoS One. 2017 Jan 3;12(1):e0168775. doi: 10.1371/journal.pone.0168775. eCollection 2017. PubMed PMID: 28045943; PubMed Central PMCID: PMC5207785.
10: Worst EG, Exner MP, De Simone A, Schenkelberger M, Noireaux V, Budisa N, Ott A. Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System. J Vis Exp. 2016 Aug 1;(114). doi: 10.3791/54273. PubMed PMID: 27500416; PubMed Central PMCID: PMC5091720.
11: Krasuska U, Andrzejczak O, Staszek P, Bogatek R, Gniazdowska A. Canavanine Alters ROS/RNS Level and Leads to Post-translational Modification of Proteins in Roots of Tomato Seedlings. Front Plant Sci. 2016 Jun 14;7:840. doi: 10.3389/fpls.2016.00840. eCollection 2016. PubMed PMID: 27379131; PubMed Central PMCID: PMC4905978.
12: Krasuska U, Ciacka K, Orzechowski S, Fettke J, Bogatek R, Gniazdowska A. Modification of the endogenous NO level influences apple embryos dormancy by alterations of nitrated and biotinylated protein patterns. Planta. 2016 Oct;244(4):877-91. doi: 10.1007/s00425-016-2553-z. Epub 2016 Jun 14. PubMed PMID: 27299743.
13: Krasuska U, Andrzejczak O, Staszek P, Borucki W, Gniazdowska A. Toxicity of canavanine in tomato (Solanum lycopersicum L.) roots is due to alterations in RNS, ROS and auxin levels. Plant Physiol Biochem. 2016 Jun;103:84-95. doi: 10.1016/j.plaphy.2016.03.005. Epub 2016 Mar 5. PubMed PMID: 26986929.
14: Nurcahyanti AD, Wink M. L-Canavanine Potentiates Cytotoxicity of Chemotherapeutic Drugs in Human Breast Cancer Cells. Anticancer Agents Med Chem. 2017;17(2):206-211. PubMed PMID: 26902604.
15: Nurcahyanti AD, Wink M. L-Canavanine potentiates the cytotoxicity of doxorubicin and cisplatin in arginine deprived human cancer cells. PeerJ. 2016 Jan 7;4:e1542. doi: 10.7717/peerj.1542. eCollection 2016. PubMed PMID: 26839743; PubMed Central PMCID: PMC4734457.
16: Matsui D, Terai A, Asano Y. L-Arginine oxidase from Pseudomonas sp. TPU 7192: Characterization, gene cloning, heterologous expression, and application to L-arginine determination. Enzyme Microb Technol. 2016 Jan;82:151-157. doi: 10.1016/j.enzmictec.2015.10.002. Epub 2015 Oct 9. PubMed PMID: 26672462.
17: Nyazika TK, Robertson VJ, Nherera B, Mapondera PT, Meis JF, Hagen F. Comparison of biotyping methods as alternative identification tools to molecular typing of pathogenic Cryptococcus species in sub-Saharan Africa. Mycoses. 2016 Mar;59(3):151-6. doi: 10.1111/myc.12444. Epub 2015 Dec 10. PubMed PMID: 26661484; PubMed Central PMCID: PMC4761295.
18: Nurcahyanti AD, Wink M. Cytotoxic potentiation of vinblastine and paclitaxel by L-canavanine in human cervical cancer and hepatocellular carcinoma cells. Phytomedicine. 2015 Dec 15;22(14):1232-7. doi: 10.1016/j.phymed.2015.10.007. Epub 2015 Oct 30. PubMed PMID: 26655405.
19: Ott AK, Locher L, Koch M, Deuerling E. Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae. PLoS One. 2015 Nov 30;10(11):e0143457. doi: 10.1371/journal.pone.0143457. eCollection 2015. PubMed PMID: 26618777; PubMed Central PMCID: PMC4664479.
20: Shim J, Lee Y, Jeong YT, Kim Y, Lee MG, Montell C, Moon SJ. The full repertoire of Drosophila gustatory receptors for detecting an aversive compound. Nat Commun. 2015 Nov 16;6:8867. doi: 10.1038/ncomms9867. PubMed PMID: 26568264; PubMed Central PMCID: PMC4660205.

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