(R)-(-)-JQ1 Enantiomer


CAS No. : 1268524-71-5

(R)-(-)-JQ1 Enantiomer,1268524-71-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013976
Molecular Formula:C₂₃H₂₅ClN₄O₂S
Molecular Weight:456.99
Target: Epigenetic Reader Domain
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Cat No:I013976
Cas No:1268524-71-5
Product-Name:(R)-(-)-JQ1 Enantiomer
InChI:InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1
InChIKey:DNVXATUJJDPFDM-QGZVFWFLSA-N
SMILES:CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
(-)-JQ-1 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (−)-JQ1 has no effect.
[1]. Filippakopoulos, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
[2]. Mahe M, et al. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers. EMBO Mol Med. 2018 Feb 20. pii: e8163.
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