(beta)-Apo-13-carotenone


CAS No. : 17974-57-1

(beta)-Apo-13-carotenone,17974-57-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013397
Molecular Formula:C₁₈H₂₆O
Molecular Weight:258.4
Target:Others
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Cat No:I013397
Cas No:17974-57-1
Product-Name:(beta)-Apo-13-carotenone
IUPAC Name:(3E,5E,7E)-6-methyl-8-(2,6,6-trimethylcyclohexen-1-yl)octa-3,5,7-trien-2-one
InChI:InChI=1S/C18H26O/c1-14(8-6-10-16(3)19)11-12-17-15(2)9-7-13-18(17,4)5/h6,8,10-12H,7,9,13H2,1-5H3/b10-6+,12-11+,14-8+
InChIKey:UBTNVRPIHJRBCI-LUXGDSJYSA-N
SMILES:CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=O)C)C
β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
[1]. Eroglu A, et al. The eccentric cleavage product of β-carotene, β-apo-13-carotenone, functions as an antagonist of RXRα. Arch Biochem Biophys. 2010 Dec 1;504(1):11-6.
[2]. Sun J, et al. β-Apo-13-carotenone regulates retinoid X receptor transcriptional activity through tetramerization of the receptor. J Biol Chem. 2014 Nov 28;289(48):33118-24.
[3]. Wang CX, et al. Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes. Arch Biochem Biophys. 2015 Apr 15;572:2-10.
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