Squalamine lactate

CAS No. : 320725-47-1

Squalamine lactate,320725-47-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013055
Molecular Formula:C₃₇H₇₁N₃O₈S
Molecular Weight:718.04
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Cat No:I013055
Cas No:320725-47-1
Product-Name:Squalamine lactate
IUPAC Name:[(3R,6R)-6-[(3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-[3-(4-aminobutylamino)propylamino]-7-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-3-yl] hydrogen sulfate;(2S)-2-hydroxypropanoic acid
Squalamine lactate(cas  320725-47-1) is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.
OriginatorGenaera Corporation
DeveloperGenaera Corporation; NeuBase Therapeutics
ClassAntineoplastics; Cholestanols; Eye disorder therapies; Lactates; Small molecules
Mechanism of ActionAngiogenesis inhibitors; Platelet-derived growth factor inhibitors; Vascular endothelial growth factor C inhibitors
Orphan Drug StatusYes - Ovarian cancer
New Molecular EntityYes
[1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.
[2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.

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