C188-9


CAS No. : 432001-19-9

C188-9,432001-19-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I011120
Synonyms:C188-9; TTI-101;
Molecular Formula:C27H21NO5S
Molecular Weight:471.527
Target:STAT3
IC50:4.7 nM(Kd)
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Cat No:I011120
Cas No:432001-19-9
Product-Name:C188-9
IUPAC Name:N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)naphthalen-1-yl]-4-methoxybenzenesulfonamide
InChI:InChI=1S/C27H21NO5S/c1-33-18-11-13-19(14-12-18)34(31,32)28-24-16-23(27(30)22-9-5-4-8-21(22)24)26-20-7-3-2-6-17(20)10-15-25(26)29/h2-16,28-30H,1H3
InChIKey:QDCJDYWGYVPBDO-UHFFFAOYSA-N
SMILES:COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O
C188-9(cas 432001-19-9) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.
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