(±)-AMG 487

CAS No. : 947536-03-0

(±)-AMG 487,947536-03-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I010967
Molecular Formula:C32H28F3N5O4
Molecular Weight:603.602
Target:Chemokine Receptors
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Cat No:I010967
Cas No:947536-03-0
Product-Name:(±)-AMG 487
IUPAC Name:N-[1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.
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