Medetomidine Hydrochloride


CAS No. : 86347-15-1

Medetomidine Hydrochloride,86347-15-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I007942
Synonyms:MPV-785; MPV 785; MPV785; Medetomidine HCl; Medetomidine hydrochloride; Precedex. Domitor. Selektope.;4-(1-(2,3-dimethylphenyl)ethyl)-1H-imidazole hydrochloride
Molecular Formula:C13H17ClN2
Molecular Weight:236.743
Target:Adrenergic Receptor
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Appearance:Solid powder
Purity: > 98%
Cat No:I007942
Cas No:86347-15-1
Product-Name:Medetomidine Hydrochloride
InChI:InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H
InChIKey:VPNGEIHDPSLNMU-UHFFFAOYSA-N
SMILES:CC(C1=CNC=N1)C2=CC=CC(C)=C2C.[H]Cl
Medetomidine(cas 86347-15-1), also known as MPV-785, is a synthetic drug used as both a surgical anesthetic and analgesic. It is an alpha-2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water. It is currently approved for dogs in the United States. Medetomidine is a racemic mixture of two stereoisomers; dexmedetomidine is the isomer with more useful effects, and is now marketed as Dexdomitor. Medetomidine can be used as an antifouling substance in marine paint. It is mainly effective against barnacles.
1:Acta Vet Scand Suppl. 1989;85:103-10. Medetomidine as a preanesthetic prior to ketamine-HCL and halothane anesthesia in laboratory beagles.Räihä JE,Räihä MP,Short CE, PMID: 2571257
Abstract: The potent sedative and analgesic effects of medetomidine confirm its potential use as a premedication to general anesthesia in dogs. In this study two different doses of medetomidine were tested as premedication to both ketamine HCl and halothane anesthesia in groups consisting of 4 laboratory beagles each. Cardiopulmonary parameters, anesthetic quality and dose requirements were recorded. Medetomidine was found to have favorable qualities in conjunction with these anesthetics. Atropine prevented the profound bradycardia and sinus arrhythmia seen with medetomidine alone. Cardiopulmonary parameters remained satisfactory in both groups, but no additional benefits could be seen from doses of 40 micrograms/kg medetomidine compared to 20 micrograms/kg, except a significant 30% reduction in halothane requirement. The positive chronotropic and inotropic properties of ketamine restored the medetomidine induced bradycardia and produced a short anesthetic period of 15-30 min depending on the dose of medetomidine. The quality of anesthesia was good in both groups, but recovery was quicker and smoother in the group with 20 micrograms/kg medetomidine.
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