LDN-91946


CAS No. : 439946-22-2

LDN-91946,439946-22-2
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I007636
Synonyms:LDN-91946; LDN 91946; LDN91946.;3-amino-2-(benzoyl)-6-oxo-7H-thieno[3,2-e]pyridine-5-carboxylic acid
Molecular Formula:C15H10N2O4S
Molecular Weight:314.347
Target:UCH-L1 inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:I007636
Cas No:439946-22-2
Product-Name:LDN-91946
IUPAC Name:3-amino-2-benzoyl-6-oxo-4,5,7,7a-tetrahydro-3aH-thieno[2,3-b]pyridine-5-carboxylic acid
InChI:InChI=1S/C15H14N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-5,8-9,14H,6,16H2,(H,17,19)(H,20,21)
InChIKey:OQYOQOZZWGXGLT-UHFFFAOYSA-N
SMILES:C1C2C(NC(=O)C1C(=O)O)SC(=C2N)C(=O)C3=CC=CC=C3
LDN-91946 is a potent, selective and uncompetitive UCH-L1 inhibitor that targets the enzyme-substrate complex.

1:Coulombe J, Gamage P, Gray MT, Zhang M, Tang MY, Woulfe J, Saffrey MJ, Gray DA. Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system. Front Aging Neurosci. 2014 Jun 19;6:129. doi: 10.3389/fnagi.2014.00129. PubMed PMID: 24994982; PubMed Central PMCID: PMC4063237.
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