Evogliptin HCl


CAS No. : 1246960-27-9 (HCl).

Evogliptin HCl,1246960-27-9 (HCl).
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I006744
Synonyms:DA-1229; DA 1229; DA1229; Evogliptin; Evogliptin hydrochloride.;(R)-4-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one hydrochloride
Molecular Formula:C19H27ClF3N3O3
Molecular Weight:437.8882
Target:DPP4 inhibitor
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Appearance:Solid powder
Purity: > 98%
Cat No:I006744
Cas No:1246960-27-9 (HCl).
Product-Name:Evogliptin HCl
InChI:InChI=1S/C19H26F3N3O3.ClH/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20;/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27);1H/t12-,16-;/m1./s1
InChIKey:QHQXWMKKQNSBTC-VQZRABBESA-N
SMILES:O=C1NCCN(C(C[[email protected]](N)CC2=CC(F)=C(F)C=C2F)=O)[[email protected]@H]1COC(C)(C)C.[H]Cl
Evogliptin, also known as DA-1229, is a potent and selective DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor). Evogliptin improves insulin resistance and delays the onset of diabetes. Evogliptin improves the insulin sensitivity in HF mice and delays the onset of diabetes in young db/db mice. DA-1229 monotherapy (5 mg for 12 weeks) improved HbA1c, fasting plasma glucose level, OGTT results and β-cell function. This drug was well tolerated in Korean subjects with type 2 diabetes mellitus.

1:Jung CH, Park CY, Ahn KJ, Kim NH, Jang HC, Lee MK, Park JY, Chung CH, Min KW, Sung YA, Park JH, Kim SJ, Lee HJ, Park SW. A randomized, double-blind, placebo-controlled, phase II clinical trial to investigate the efficacy and safety of oral DA-1229 in patients with type 2 diabetes mellitus who have inadequate glycaemic control with diet and exercise. Diabetes Metab Res Rev. 2015 Mar;31(3):295-306. doi: 10.1002/dmrr.2613. Epub 2014 Dec 5. PubMed PMID: 25362864; PubMed Central PMCID: PMC4670720.

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