CGS-21680 HCl


CAS No. : 124431-80-7 (HCl); 120225-54-9 (free)

CGS-21680 HCl,124431-80-7 (HCl); 120225-54-9 (free)
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I006071
Synonyms:CGS21680; CGS-21680; CGS 21680; CGS-21680 HCl; CGS-21680 hydrochloride.;3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid hydrochloride
Molecular Formula:C23H30ClN7O6
Molecular Weight:535.9806
Target:adenosine A2A agonist
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Appearance:Solid powder
Purity: > 98%
Cat No:I006071
Cas No:124431-80-7 (HCl); 120225-54-9 (free)
Product-Name:CGS-21680 HCl
MDL No:MFCD00078573
SMILES:O=C(O)CCC1=CC=C(CCNC2=NC(N)=C3N=CN([[email protected]@H]4O[[email protected]](C(NCC)=O)[[email protected]@H](O)[[email protected]]4O)C3=N2)C=C1.[H]Cl
CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin. The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

1:Jones-Cage C, Stratford TR, Wirtshafter D. Differential effects of the adenosine A(2A) agonist CGS-21680 and haloperidol on food-reinforced fixed ratio responding in the rat. Psychopharmacology (Berl). 2011 Sep 7. [Epub ahead of print] PubMed PMID: 21898173.

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