Appearance:Solid powderPurity: > 98%
CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin. The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.
1：Jones-Cage C, Stratford TR, Wirtshafter D. Differential effects of the adenosine A(2A) agonist CGS-21680 and haloperidol on food-reinforced fixed ratio responding in the rat. Psychopharmacology (Berl). 2011 Sep 7. [Epub ahead of print] PubMed PMID: 21898173.