(-)-Epigallocatechin gallate

CAS No. : 989-51-5

(-)-Epigallocatechin gallate,989-51-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I005735
Synonyms:[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Molecular Formula:C₂₂H₁₈O₁₁
Molecular Weight:458.37
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Cat No:I005735
Cas No:989-51-5
Product-Name:(-)-Epigallocatechin gallate
MDL No:MFCD00075940

Epigallocatechol Gallate(EGCG) is an antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors.

(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, with broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDL) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. After treating with EGCG, the expressions of HES1 and Notch2 was obviously inhibited, this indicated that EGCG inhibited colorectal cancer by inhibiting HES1 and Notch2.

1:Comparison of the impact of epigallocatechin gallate and ellagic acid in an experimental cataract model induced by sodium selenite. Ergen I, Turgut B, Ilhan N.Int J Ophthalmol. 2017 Apr 18;10(4):499-506. doi: 10.18240/ijo.2017.04.01. eCollection 2017. PMID: 28503419 Free PMC Article
2:Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C.J Biol Chem. 2017 May 9. pii: jbc.C117.787309. doi: 10.1074/jbc.C117.787309. [Epub ahead of print] PMID: 28487468 Free Article
3:Epigallocatechin gallate inhibits the growth of salivary adenoid cystic carcinoma cells via the EGFR/Erk signal transduction pathway and the mitochondria apoptosis pathway. Weng LX, Wang GH, Yao H, Yu MF, Lin J.Neoplasma. 2017 May 9;64. doi: 10.4149/neo_2017_410. [Epub ahead of print] PMID: 28485162
4:Study on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats. Liu Y, Zhang D, Wang Y, Zhang W, Liu X.Xenobiotica. 2017 May 4:1-40. doi: 10.1080/00498254.2017.1326187. [Epub ahead of print] PMID: 28471331
5:Mechanism of Anti-rotavirus Synergistic Activity by Epigallocatechin Gallate and a Proanthocyanidin-Containing Nutraceutical. Lipson SM, Karalis G, Karthikeyan L, Ozen FS, Gordon RE, Ponnala S, Bao J, Samarrai W, Wolfe E.Food Environ Virol. 2017 May 2. doi: 10.1007/s12560-017-9299-z. [Epub ahead of print] PMID: 28466464
6:Probing the inhibitory activity of epigallocatechin-gallate on toxic aggregates of mutant (L84F) SOD1 protein through geometry based sampling and steered molecular dynamics. Srinivasan E, Rajasekaran R.J Mol Graph Model. 2017 Apr 20;74:288-295. doi: 10.1016/j.jmgm.2017.04.019. [Epub ahead of print] PMID: 28458007
7:Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1. Sun W, Liu X, Zhang H, Song Y, Li T, Liu X, Liu Y, Guo L, Wang F, Yang T, Guo W, Wu J, Jin H, Wu H.Free Radic Biol Med. 2017 Apr 27;108:840-857. doi: 10.1016/j.freeradbiomed.2017.04.365. [Epub ahead of print] PMID: 28457936
8:Encapsulation of epigallocatechin gallate in zein/chitosan nanoparticles for controlled applications in food systems. Liang J, Yan H, Wang X, Zhou Y, Gao X, Puligundla P, Wan X.Food Chem. 2017 Sep 15;231:19-24. doi: 10.1016/j.foodchem.2017.02.106. Epub 2017 Feb 22. PMID: 28449996
9:(-)-Epigallocatechin Gallate Targets Notch to Attenuate the Inflammatory Response in the Immediate Early Stage in Human Macrophages. Wang T, Xiang Z, Wang Y, Li X, Fang C, Song S, Li C, Yu H, Wang H, Yan L, Hao S, Wang X, Sheng J.Front Immunol. 2017 Apr 10;8:433. doi: 10.3389/fimmu.2017.00433. eCollection 2017. PMID: 28443100 Free PMC Article
10:Epigallocatechin gallate protects BEAS-2B cells from lipopolysaccharide-induced apoptosis through upregulation of gastrin-releasing peptide. Divya P, Puthusseri B, Manual DJK, Savanur MA.Mol Cell Biochem. 2017 Apr 21. doi: 10.1007/s11010-017-3040-y. [Epub ahead of print] PMID: 28432554
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