(S)-(+)-Rolipram


CAS No. : 85416-73-5

(S)-(+)-Rolipram,85416-73-5
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I005129
Synonyms:(4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Molecular Formula:C16H21NO3
Molecular Weight:275.34
Target:PDE
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Cat No:I005129
Cas No:85416-73-5
Product-Name:(S)-(+)-Rolipram

(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R enantiomer.
Target: PDE4B; PDE4D
Rolipram, a selective inhibitor of the cyclic AMP-specific phosphodiesterase (PDE IV). Rolipram did not inhibit 5-lipoxygenase activity but did inhibit human monocyte production of leukotriene B4 (LTB4, IC50 3.5 microM). Rolipram inhibited arachidonic acid-induced inflammation in the mouse, while the low Km-cyclic-GMP PDE inhibitor. Rolipram had a modest effect on LTB4 production in the mouse, but markedly reduced LTB4-induced PMN infiltration [1]. In humans and animals rolipram produces thereby a variety of biological effects. These effects include attenuation of endogenous depression and inflammation in the central nervous system (CNS), both effects are of potential clinical relevance [2].


[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44.
[2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98.

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