(R)-Baclofen hydrochloride


CAS No. : 63701-55-3

(R)-Baclofen hydrochloride,63701-55-3
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I004405
Synonyms:(3R)-4-amino-3-(4-chlorophenyl)butanoic acid;hydrochloride
Molecular Formula:C10H13Cl2NO2
Molecular Weight:250.12
Target:GABA Receptor
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Cat No:I004405
Cas No:63701-55-3
Product-Name:(R)-Baclofen hydrochloride

(R)-Baclofen hydrochloride is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.
Target: GABA
Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.
It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups, and has been shown to prevent rises in body temperature induced by the drug MDMA in rats.In addition, research has shown baclofen to be effective in the treatment of alcohol dependence and withdrawal, by inhibiting both withdrawal symptoms andcravings.


[1]. Mezler M, et al. Cloning and functional expression of GABA(B) receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86.
[2]. Dzitoyeva S, et al. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11.

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