5949-44-0|Testosterone undecanoate|MuseChem

Testosterone undecanoate


CAS No. : 5949-44-0

Testosterone undecanoate,5949-44-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I004230
Synonyms:Andriol; 5949-44-0; Undestor; Nebido; Testosterone undecylate
Molecular Formula:C30H48O3
Molecular Weight:456.7
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Appearance: Powder
Purity: 98.0%
Cat No:I004230
Cas No:5949-44-0
Product-Name:Testosterone undecanoate
MDL No:MFCD00468114
InChI:1S/C30H48O3/c1-4-5-6-7-8-9-10-11-12-28(32)33-27-16-15-25-24-14-13-22-21-23(31)17-19-29(22,2)26(24)18-20-30(25,27)3/h21,24-27H,4-20H2,1-3H3/t24-,25-,26-,27-,29-,30-/m0/s1
InChIKey:UDSFVOAUHKGBEK-CNQKSJKFSA-N
SMILES:CCCCCCCCCCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Testosterone undecanoate is an ester of testosterone; used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.
1: Lachance S, Dhingra O, Bernstein J, Gagnon S, Savard C, Pelletier N, Boudreau N, Lévesque A. Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials. Future Sci OA. 2015 Nov 1;1(4):FSO55. doi: 10.4155/fso.15.55. eCollection 2015 Nov. PubMed PMID: 28031910; PubMed Central PMCID: PMC5137954.
2: Hackett G, Cole N, Saghir A, Jones P, Strange RC, Ramachandran S. Testosterone undecanoate improves sexual function in men with type 2 diabetes and severe hypogonadism: results from a 30-week randomized placebo-controlled study. BJU Int. 2016 Nov;118(5):804-813. doi: 10.1111/bju.13516. Epub 2016 May 27. PubMed PMID: 27124889.
3: Chillarón JJ, Fernández-Miró M, Albareda M, Fontserè S, Colom C, Vila L, Pedro-Botet J, Flores Le-Roux JA. Testosterone undecanoate improves lipid profile in patients with type 1 diabetes and hypogonadotrophic hypogonadism. Endocr J. 2016 Sep 30;63(9):849-855. Epub 2016 Jul 22. PubMed PMID: 27452372.
4: Permpongkosol S, Khupulsup K, Leelaphiwat S, Pavavattananusorn S, Thongpradit S, Petchthong T. Effects of 8-Year Treatment of Long-Acting Testosterone Undecanoate on Metabolic Parameters, Urinary Symptoms, Bone Mineral Density, and Sexual Function in Men With Late-Onset Hypogonadism. J Sex Med. 2016 Aug;13(8):1199-211. doi: 10.1016/j.jsxm.2016.06.003. PubMed PMID: 27436076.
5: Gan EH, Bouloux PM, Quinton R. Unexpectedly prolonged washout period of exogenous testosterone after discontinuation of intramuscular testosterone undecanoate depot injection (Nebido(®) or Reandron(®) ) in men with congenital hypogonadotrophic hypogonadism. Clin Endocrinol (Oxf). 2016 Jun;84(6):947-50. doi: 10.1111/cen.13018. Epub 2016 Feb 10. PubMed PMID: 26732131.
6: Tungmunsakulchai R, Chaikittisilpa S, Snabboon T, Panyakhamlerd K, Jaisamrarn U, Taechakraichana N. Effectiveness of a low dose testosterone undecanoate to improve sexual function in postmenopausal women. BMC Womens Health. 2015 Dec 2;15:113. doi: 10.1186/s12905-015-0270-6. PubMed PMID: 26631095; PubMed Central PMCID: PMC4668626.
7: Zhang XW, Zhang C, Zhang W, Yang D, Meng S, Wang P, Guo J, Liu DH. Suppression of spermatogenesis by testosterone undecanoate-loaded injectable in situ-forming implants in adult male rats. Asian J Androl. 2016 Sep-Oct;18(5):791-7. doi: 10.4103/1008-682X.160886. PubMed PMID: 26459781; PubMed Central PMCID: PMC5000806.
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