Azatadine dimaleate

Appearance:Solid powder
Purity: > 98%

Cat No:	I003451
Cas No:	3978-86-7
Product-Name:	Azatadine dimaleate
IUPAC Name:	(Z)-but-2-enedioic acid;2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaene
InChI:	InChI=1S/C20H22N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChIKey:	SGHXFFAHXTZRQM-SPIKMXEPSA-N
SMILES:	CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C42.O=C(O)/C=CC(O)=O.O=C(O)/C=CC(O)=O

Azatadine dimaleate(CAS 3978-86-7) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

1: Hata K, Takagi M, Koga K, Shigematsu A. Stability of tritium-labelled azatadine dimaleate [6,11-dihydro-11 (1-methyl-4-piperidylidine)5H-benzo (5, 6) cyclohepta (1,2-b) pyridine dimaleate] of high specific activity. Radioisotopes. 1977 Jan;26(1):33-5. PubMed PMID: 577021.
2: Nove-Josserand G, Plauchu M. [Study of the action and tolerance of azatadine dimaleate in drug hypersensitivity]. Lyon Med. 1972 Mar 12;227(5):465-7. French. PubMed PMID: 5054522.