| Cat No: | I003450 |
| Cas No: | 3964-81-6 |
| Product-Name: | Azatadine |
| SMILES: | CN1CCC(=C2C3=CC=CC=C3CCC4=C2N=CC=C4)CC1 |
Azatadine(cas 3964-81-6) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.
Azatadine (Optimine) is a first-generation antihistamine and anticholinergic that was launched Schering-Plough in 1973.
1: Katelaris C. Comparative effects of loratadine and azatadine in the treatment
of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990 Dec;8(2):103-7.
PubMed PMID: 1982614.
2: Togias AG, Naclerio RM, Warner J, Proud D, Kagey-Sobotka A, Nimmagadda I,
Norman PS, Lichtenstein LM. Demonstration of inhibition of mediator release from
human mast cells by azatadine base. In vivo and in vitro evaluation. JAMA. 1986
Jan 10;255(2):225-9. PubMed PMID: 2416958.
3: Zubizaretta J. Azatadine maleate/pseudoephedrine sulfate repetabs versus
placebo in the treatment of severe perennial allergic rhinitis. J Int Med Res.
1980;8(6):395-9. PubMed PMID: 6108263.
4: Biehl B. Effects of azatadine maleate on subjective appraisal and psychomotor
functions relevant to driving performance. Curr Med Res Opin. 1979;6(1):62-9.
PubMed PMID: 37045.
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