Chlormadinone acetate

CAS No. : 302-22-7

Chlormadinone acetate,302-22-7
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I003055
Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione; 17-Acetoxy-6-chloro-6-dehydroprogesterone; 6-Chloro-17-acetoxy-4,6-pregnadiene-3,20-dione; Chronosyn; Fertiletten;
Molecular Formula:C23H29ClO4
Molecular Weight:404.93
Target:Estrogen/progestogen Receptor
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Cat No:I003055
Cas No:302-22-7
Product-Name:Chlormadinone acetate
Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.
Chlormadinone acetate (abbreviated as CMA) (INN, USAN, BAN, JAN) (sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon, Normenon, Verton, and many others), and also known as 17α-acetoxy-6-chloro-6-dehydroprogesterone, is a steroidal progestin with additional antiandrogen and antigonadotropic (and by extension antiestrogenic) effects. CMA has been used in the treatment of vaginal bleeding, oligomenorrhea, polymenorrhea, hypermenorrhea, secondary amenorrhea, and endometriosis. It has also been used clinically as a hormonal contraceptive, and in part due to its capacity to lower estrogen levels, but also for improved effectiveness in contraception, chlormadinone has frequently been combined with ethinylestradiol for this purpose.
1: Kim SM, Lee BN, Koh JT, Chang HS, Hwang IN, Oh WM, Min KS, Hwang YC. The effect of chlormadinone acetate on odontogenic differentiation of human dental pulp cells: in vitro study. BMC Oral Health. 2017 May 26;17(1):89. doi: 10.1186/s12903-017-0379-0. PubMed PMID: 28549486; PubMed Central PMCID: PMC5446736.
2: Siegenthaler PF, Zhao Y, Zhang K, Fent K. Reproductive and transcriptional effects of the antiandrogenic progestin chlormadinone acetate in zebrafish (Danio rerio). Environ Pollut. 2017 Apr;223:346-356. doi: 10.1016/j.envpol.2017.01.031. Epub 2017 Jan 22. PubMed PMID: 28118999.
3: Grandi G, Napolitano A, Xholli A, Tirelli A, Di Carlo C, Cagnacci A. Effect of oral contraceptives containing estradiol and nomegestrol acetate or ethinyl-estradiol and chlormadinone acetate on primary dysmenorrhea. Gynecol Endocrinol. 2015 Oct;31(10):774-8. doi: 10.3109/09513590.2015.1063118. Epub 2015 Aug 17. PubMed PMID: 26291811.
4: Yildizhan R, Gokce AI, Yildizhan B, Cim N. Comparison of the effects of chlormadinone acetate versus drospirenone containing oral contraceptives on metabolic and hormonal parameters in women with PCOS for a period of two-year follow-up. Gynecol Endocrinol. 2015 May;31(5):396-400. doi: 10.3109/09513590.2015.1006187. Epub 2015 Mar 4. PubMed PMID: 25739031.
5: Kim JM, Lee JE, Ryu SH, Suh PG. Chlormadinone acetate promotes osteoblast differentiation of human mesenchymal stem cells through the ERK signaling pathway. Eur J Pharmacol. 2014 Mar 5;726:1-8. PubMed PMID: 24440171.
6: Gahr M, Freudenmann RW, Connemann BJ, Kölle MA, Schönfeldt-Lecuona C. Rapid relapse in depression following initialization of oral contraception with ethinyl estradiol and chlormadinone acetate. Gen Hosp Psychiatry. 2014 Mar-Apr;36(2):230.e1-2. doi: 10.1016/j.genhosppsych.2013.10.014. Epub 2013 Oct 30. PubMed PMID: 24287129.
7: Koike H, Morikawa Y, Matsui H, Shibata Y, Ito K, Suzuki K. Chlormadinone acetate is effective for hot flush during androgen deprivation therapy. Prostate Int. 2013;1(3):113-6. doi: 10.12954/PI.12010. Epub 2013 Sep 27. PubMed PMID: 24223412; PubMed Central PMCID: PMC3814123.
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