AMG-510


CAS No. : 2252403-56-6

AMG-510,2252403-56-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I001014
Synonyms:AMG-510;AMG510;
Molecular Formula:C30H30F2N6O3
Molecular Weight:560.6
Target:KRAS
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Inventory Status:In stock!
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Appearance:Solid powder
Purity:98%(HPLC)
Cat No:I001014
Cas No:2252403-56-6
Product-Name:AMG-510
Related Cas: 2296729-00-3 (racemate)
IUPAC Name:6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
InChI:InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChIKey:NXQKSXLFSAEQCZ-SFHVURJKSA-N
SMILES:CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
AMG-510(cas 2252403-56-6) is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells
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