CAS No. : 11089-65-9

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000442
Molecular Formula:C₃₈H₆₂N₄O₆
Molecular Weight:830.93
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Cat No:I000442
Cas No:11089-65-9
MDL No:MFCD00065709
SMILES:O[[email protected]]1[[email protected]](O)[[email protected]@H](CO)O[[email protected]](O[[email protected]]2[[email protected]](NC(/C=C/CCCCCCCCCC(C)C)=O)[[email protected]@H](O)[[email protected]@H](O)[[email protected]@H](C[[email protected]@H](O)[[em

Tunicamycin is a mixture of homologous nucleoside antibiotics. An inhibitor of glycosylation. Tunicamycin Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.
In vitro: Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER). Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation. Tunicamycin inhibite invasion, increase cell death, suppress proliferation and reduce migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture. [1]
In vivo: Administering tunicamycin further increase protein expression levels of ER stress indicators and inflammatory cytokines, and resulted in more severe asthma phenotypes in OVALPS-OVA mice. [2]

[1]. Nami B et al. Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells. Exp Toxicol Pathol. 2016 Aug;68(7):419-26.
[2]. Guo Q et al. Tunicamycin Aggravates Endoplasmic Reticulum Stress and Airway Inflammation via PERK-ATF4-CHOP Signaling in a Murine Model of Neutrophilic Asthma. J Asthma. 2016 Jul 6

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