Tunicamycin


CAS No. : 11089-65-9

Tunicamycin,11089-65-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000442
Molecular Formula:C₃₈H₆₂N₄O₆
Molecular Weight:830.93
Target:Transferase
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Cat No:I000442
Cas No:11089-65-9
Product-Name:Tunicamycin
MDL No:MFCD00065709
InChI:InChI=1S/C38H62N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h12,14-16,19,21-23,26-37,43,45,48-53H,4-11,13,17-18H2,1-
InChIKey:MEYZYGMYMLNUHJ-DIRMKAHISA-N
SMILES:O[[email protected]]1[[email protected]](O)[[email protected]@H](CO)O[[email protected]](O[[email protected]]2[[email protected]](NC(/C=C/CCCCCCCCCC(C)C)=O)[[email protected]@H](O)[[email protected]@H](O)[[email protected]@H](C[[email protected]@H](O)[[em

Tunicamycin is a mixture of homologous nucleoside antibiotics. An inhibitor of glycosylation. Tunicamycin Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis.
In vitro: Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER). Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation. Tunicamycin inhibite invasion, increase cell death, suppress proliferation and reduce migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture. [1]
In vivo: Administering tunicamycin further increase protein expression levels of ER stress indicators and inflammatory cytokines, and resulted in more severe asthma phenotypes in OVALPS-OVA mice. [2]


[1]. Nami B et al. Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells. Exp Toxicol Pathol. 2016 Aug;68(7):419-26.
[2]. Guo Q et al. Tunicamycin Aggravates Endoplasmic Reticulum Stress and Airway Inflammation via PERK-ATF4-CHOP Signaling in a Murine Model of Neutrophilic Asthma. J Asthma. 2016 Jul 6

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