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Epmedin C, a natural product, has estrogen-like effects for ovariectomized mice.
In vivo: Anesthetized with 0.4%pentobarbital sodium, mice of the ovariectomized group were conducted with Bilateral oophorectomy, while fat beside ovaries were removed on mice of the sham-operation group. Compared with the sham-operation group, body weight of mice of model group were significantly increased, uterus weight and uterine factor and estradiol levels were significantly reduced, which suggested a significant difference. In comparison of the ovariectomized group, body weight of mice were relieved significantly and uterus weight and uterine factor and estradiol levels were increased significantly in all Epmedin C groups .
. WEN Yu, et al. Effect of Epmedin C on Estrogen in Ovariectomized Mice. Modern Chinese Medicine, 2012-05