ML-7 hydrochloride


CAS No. : 110448-33-4

ML-7 hydrochloride,110448-33-4
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000430
Synonyms:1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride
Molecular Formula:C15H17IN2O2S • HCl
Molecular Weight:452.7
Target:ATPase
IC50:300 nM (Ki)
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Appearance:Solid powder
Purity: > 98%
Cat No:I000430
Cas No:110448-33-4
Product-Name:ML-7 hydrochloride
InChI:InChI=1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChIKey:KDDALCDYHZIZMH-UHFFFAOYSA-N
SMILES:O=S(C1=CC=CC2=C1C=CC=C2I)(N3CCCNCC3)=O.Cl

ML-7 Hcl is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM); also inhibt smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA).
IC50 value: 300 nM (Ki)
Target: myosin


1:Selective inhibition of collagen-induced arachidonic acid liberation by 1-(5-iodonaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), a myosin light chain kinase inhibitor, in washed rabbit platelets. Matsuoka I, Nakahata N, Nakanishi H.Biochem Pharmacol. 1997 Nov 1;54(9):1019-26. PMID: 9374423
2:Activity of 4/'-0-tetrahydropyranyladriamycin hydrochloride (THP-ADM) in a human tumor cloning system. Inoue K, Arakawa M, Miyamoto H, Ogawa M.Invest New Drugs. 1983;1(4):271-5. PMID: 6687222
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