Paroxetine hydrochloride hemihydrate

CAS No. : 110429-35-1

Paroxetine hydrochloride hemihydrate,110429-35-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000429
Molecular Formula:C19H22ClFNO3.5
Molecular Weight:374.83
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Cat No:I000429
Cas No:110429-35-1
Product-Name:Paroxetine hydrochloride hemihydrate

Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs).
Target: SSRIs
Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. Paroxetine likely inhibits the reuptake of serotonin at the neuronal membrane, enhances serotonergic neurotransmission by reducing turnover of the neurotransmitter, therefore it prolongs its activity at synaptic receptor sites and potentiates 5-HT in the CNS [1]. Paroxetine produced a significantly greater reduction in LSAS total score (mean change from baseline: -29.4 v. -15.6; P < or = 0.001) and a greater proportion of responders (score < or = 2 on CGI global improvement) (65.7% v. 32.4%; P < 0.001) compared with placebo at the end of the 12-week study period. Both primary efficacy variables were statistically significant compared with placebo from week 4 onwards. Paroxetine was generally well tolerated [2]. Paroxetine 20 mg/day exerted a strong delay (8.9-fold increase), whereas citalopram 20 mg/day mildly delayed ejaculation (1.8-fold increase). These results indicate that paroxetine leads to a significant delay in orgasm and ejaculation, whereas citalopram seems to have less of an effect on it [3].

[1]. Meyer, J.H., et al., The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study. Am J Psychiatry, 2001. 158(1): p. 78-85.
[2]. Baldwin, D., et al., Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group. Br J Psychiatry, 1999. 175: p. 120-6.
[3]. Waldinger, M.D., A.H. Zwinderman, and B. Olivier, SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram. J Clin Psychopharmacol, 2001. 21(6): p. 556-60.

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