CAS No. : 110267-81-7

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000423
Molecular Formula:C25H25NO9
Molecular Weight:483.47
Price:Get quote
We would like to match the lowest price on market if possible.

Your information is safe with us.

Cat No:I000423
Cas No:110267-81-7

Amrubicin(SM-5887) is a novel anthracycline derivative for treatment of bladder carcinoma.
Target: Others
Amrubicin (SM-5887) is an anthracycline used in the treatment of lung cancer. The distribution of SM-5887 in the bladder mucosa and muscular layer was almost equal, but the concentration of its active metabolite, 13-OH derivative, was 5 to 10 times higher in the bladder mucosa than in the bladder muscular layer. The distributions of SM-5887 in the organs other than the bladder, that is, the cortex and medulla of kidney, heart, lung, liver, and spleen, were very low, and those of a 13-OH active metabolite were even lower. In addition, SM-5887 barely affected the normal bladder mucosa. In dogs instilled with 80 mg of SM-5887, no histological change was observed in the bladder mucosa and submucosal layer even after 6-hour retention at the highest concentration of 8,000 micrograms/ml [1]. phase II clinical trial of SM-5887, a new totally synthesized anthracycline derivative, was carried out in 13 patients with inoperable or recurrent gastric cancer. No patient had been given anthracycline previously. SM-5887 was administered by I.V. bolus with a dose of 100 mg/m2 every three weeks. Twelve of 13 cases were eligible and evaluable for the response. Of the 12 evaluated cases, 6 showed no change (NC), including one minor response (MR) [2].

[1]. Ohmori, H., T. Tsushima, and K. Kobashi, [Experimental studies on intravesical instillation of SM-5887, a novel anthracycline derivative for treatment of bladder carcinoma]. Gan To Kagaku Ryoho, 1996. 23(5): p. 601-6.
[2]. Tsushima, K., et al., [A phase II study of SM-5887 for advanced gastric cancer]. Gan To Kagaku Ryoho, 1991. 18(7): p. 1151-4.

Related Products
  • CAS No. :123948-87-8
    Product Name:


    Cat No: I000954 View details
  • CAS No. :69408-81-7
    Product Name:


    Cat No: I004608 View details
  • CAS No. :175414-77-4
    Product Name:


    Cat No: I002287 View details
  • CAS No. :72496-41-4
    Product Name:


    Cat No: A000632 View details